Rho GTPases regulate cytoskeletal and cell adhesion dynamics and thereby coordinate a
wide range of cellular processes, including cell migration, cell polarity and cell cycle …

Protein lipidation, including cysteine prenylation, N-terminal glycine myristoylation, cysteine
palmitoylation, and serine and lysine fatty acylation, occurs in many proteins in eukaryotic …

Protein S-acylation, the only fully reversible posttranslational lipid modification of proteins, is
emerging as a ubiquitous mechanism to control the properties and function of a diverse …

Abnormal Rac1 signaling is linked to a number of debilitating human diseases, including
cancer, cardiovascular diseases and neurodegenerative disorders. As such, Rac1 …

Three GTPases, RAC, RHO, and Cdc42, play essential roles in coordinating many cellular
functions during embryonic development, both in healthy cells and in disease conditions like …

Glycosylphosphatidylinositol-anchored proteins (GPI-APs) are a major class of lipid-
anchored plasma membrane proteins. GPI-APs form nanoclusters generated by cortical acto …

Abstract Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) is involved in cholesterol
homeostasis. After binding to the complex low‐density lipoprotein (LDL)‐receptor, PCSK9 …

Numerous plant defense-related proteins are thought to congregate in plasma membrane
microdomains, which consist mainly of sphingolipids and sterols. However, the extent to …

Rho GTPases are well known to regulate cell motility through activation of a variety of
downstream effector proteins, including enzymes, adaptor proteins and actin nucleators. The …

Conspectus Any chemist studying the interaction of molecules with lipid assemblies will
eventually be confronted by the topic of membrane bilayer heterogeneity and may ultimately …