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[HTML][HTML] Human skin aging and the anti-aging properties of retinol
The skin is the most-extensive and-abundant tissue in the human body. Like many organs,
as we age, human skin experiences gradual atrophy in both the epidermis and dermis. This …
as we age, human skin experiences gradual atrophy in both the epidermis and dermis. This …
Lipids and lipid metabolism in cellular senescence: Emerging targets for age-related diseases
Q Zeng, YZ Gong, N Zhu, YN Shi, CJ Zhang… - Ageing Research …, 2024 - Elsevier
Cellular senescence is a kind of cellular state triggered by endogenous or exogenous
stimuli, which is mainly characterized by stable cell cycle arrest and complex senescence …
stimuli, which is mainly characterized by stable cell cycle arrest and complex senescence …
A TBK1-independent primordial function of STING in lysosomal biogenesis
Stimulator of interferon genes (STING) is activated in many pathophysiological conditions,
leading to TBK1-dependent interferon production in higher organisms. However, primordial …
leading to TBK1-dependent interferon production in higher organisms. However, primordial …
[HTML][HTML] Cellular Senescence and Extracellular Vesicles in the Pathogenesis and Treatment of Obesity—A Narrative Review
This narrative review explores the pathophysiology of obesity, cellular senescence, and
exosome release. When exposed to excessive nutrients, adipocytes develop mitochondrial …
exosome release. When exposed to excessive nutrients, adipocytes develop mitochondrial …
Targeting lysosomal quality control as a therapeutic strategy against aging and diseases
Previously, lysosomes were primarily referred to as the digestive organelles and recycling
centers within cells. Recent discoveries have expanded the lysosomal functional scope and …
centers within cells. Recent discoveries have expanded the lysosomal functional scope and …
Heterogeneity of late endosome/lysosomes shown by multiplexed DNA-PAINT imaging
Late endosomes/lysosomes (LELs) are crucial for numerous physiological processes and
their dysfunction is linked to many diseases. Proteomic analyses have identified hundreds of …
their dysfunction is linked to many diseases. Proteomic analyses have identified hundreds of …
Senescence in the ageing skin: a new focus on m TORC 1 and the lysosome
Ageing is defined as the progressive loss of tissue function and regenerative capacity and is
caused by both intrinsic factors ie the natural accumulation of damage, and extrinsic factors …
caused by both intrinsic factors ie the natural accumulation of damage, and extrinsic factors …
[HTML][HTML] Brief guide to senescence assays using cultured mammalian cells
Cellular senescence is a crucial biological process associated with organismal aging and
many chronic diseases. Here, we present a brief guide to mammalian senescence assays …
many chronic diseases. Here, we present a brief guide to mammalian senescence assays …
Regulation of cGAS–STING signalling and its diversity of cellular outcomes
Z Zhang, C Zhang - Nature Reviews Immunology, 2025 - nature.com
The cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) signalling
pathway, which recognizes both pathogen DNA and host-derived DNA, has emerged as a …
pathway, which recognizes both pathogen DNA and host-derived DNA, has emerged as a …
H4K20me3-Mediated Repression of Inflammatory Genes Is a Characteristic and Targetable Vulnerability of Persister Cancer Cells
Anticancer therapies can induce cellular senescence or drug-tolerant persistence, two types
of proliferative arrest that differ in their stability. While senescence is highly stable, persister …
of proliferative arrest that differ in their stability. While senescence is highly stable, persister …