Univocal identification of retinal ganglion cells (RGCs) is an essential prerequisite for
studying their degeneration and neuroprotection. Before the advent of phenotypic markers …

This review explored the role of mitochondria in retinal ganglion cells (RGCs), which are
essential for visual processing. Mitochondrial dysfunction is a key factor in the pathogenesis …

This study assesses the neuroprotective potential of CPP-P1, a conjugate of an anti-
apoptotic peptain-1 (P1) and a cell-penetrating peptide (CPP) in in vitro, in vivo, and ex vivo …

Glutamate induced damage to retinal ganglion cells (RGCs) requires tight physiological
regulation of the N-methyl-D-aspartate (NMDA) receptors. Previously, studies have …

With the aging of the global population, the health care burden of Alzheimer's disease (AD)
and dementia is considered to increase dramatically in the coming decades. Given the …

Many retinal diseases are characterized by direct or indirect retinal ganglion cell (RGC)
neurodegeneration. In glaucoma and optic nerve neuropathies, RGCs are the primary …

Retinal ganglion cells (RGCs), neurons transmitting visual information via the optic nerve,
fail to regenerate their axons after injury. The progressive loss of RGC function underlies the …

Background Multiple sclerosis (MS) involves a complex interplay between immune-
mediated inflammation and neurodegeneration. Recent advances in biomarker research …

Background: Glaucoma is a progressive neurodegenerative disease characterized by
glaucomatous optic neuropathy, including loss of retinal ganglion cells and axons. Optic …

CONCLUSION Despite plenty of evidence supporting that factors other than IOP play a
major role on glaucoma onset and progression, there are currently no IOP-independent …