Metabolic reprogramming in cancer is not only a biological hallmark but also reveals
treatment vulnerabilities. Numerous metabolic molecules have shown promise as treatment …

Immunotherapy has made significant strides in cancer treatment, particularly through
immune checkpoint blockade (ICB), which has shown notable clinical benefits across …

Adenosine 5′-triphosphate citrate lyase (ACLY) is a cytosolic enzyme that converts citrate
into acetyl–coenzyme A for fatty acid and cholesterol biosynthesis. ACLY is up-regulated or …

The tumor microenvironment (TME) promotes metabolic reprogramming and dysfunction in
immune cells. Here, we examined the impact of the TME on phospholipid metabolism in …

Metabolism, including glycolysis, oxidative phosphorylation, fatty acid oxidation, and other
metabolic pathways, impacts the phenotypes and functions of immune cells. The metabolic …

Metabolic fitness of T cells is essential for their vitality, which is largely dependent on the
behavior of the mitochondria. The nature of mitochondrial behavior in tumor-infiltrating T …

Mitochondrial loss and dysfunction drive T cell exhaustion, representing major barriers to
successful T cell-based immunotherapies. Here, we describe an innovative platform to …

Prostate cancer is one of the most commonly diagnosed cancers in men and is a major
cause of cancer-related deaths worldwide. Among the molecular processes that contribute …

Effector, memory and exhaustion are three phenotypes of CD8+ T cell. In tumor
microenvironment (TME), metabolism dysfunction of the three should take the blame for …

Tumor cells reprogram their metabolism to produce specialized metabolites that both fuel
their own growth and license tumor immune evasion. However, the relationships between …