Targeting the host response in sepsis: current approaches and future evidence

C Bode, S Weis, A Sauer, P Wendel-Garcia, S David - Critical care, 2023 - Springer
Sepsis, a dysregulated host response to infection characterized by organ failure, is one of
the leading causes of death worldwide. Disbalances of the immune response play an …

Amino acid kinetics in the critically ill

NEP Deutz, KL Haines, PE Wischmeier… - Current Opinion in …, 2024 - journals.lww.com
Novel tracer and computational approaches have been developed to simultaneously
measure postabsorptive kinetics of multiple amino acids that can be used in critical illness …

Dichloroacetate as a novel pharmaceutical treatment for cancer-related fatigue in melanoma

X Zhang, WD Lee, BP Leitner, W Zhu… - American Journal …, 2023 - journals.physiology.org
Cancer-related fatigue (CRF) is one of the most common complications in patients with
multiple cancer types and severely affects patients' quality of life. However, there have only …

Verapamil and tangeretin enhances the M1 macrophages to M2 type in lipopolysaccharide-treated mice and inhibits the P-glycoprotein expression by downregulating …

A Kundu, P Ghosh, B Bishayi - International Immunopharmacology, 2024 - Elsevier
LPS induced sepsis is a complex process involving various immune cells and signaling
molecules. Dysregulation of macrophage polarization and ROS production contributed to …

An in-silico approach to identify bioactive phytochemicals from Houttuynia cordata Thunb. As potential inhibitors of human glutathione reductase

S Sangeet, A Khan - Journal of Biomolecular Structure and …, 2023 - Taylor & Francis
Cellular infections are central to the etiology of various diseases, notably cancer and
malaria. Counteracting cellular oxidative stress via the inhibition of glutathione reductase …

Cuproptosis-Related Biomarkers and Characterization of Immune Infiltration in Sepsis

Y Wang, X Qiu, J Liu, X Liu, J Pan, J Cai… - Journal of …, 2024 - Taylor & Francis
Introduction Sepsis is a worldwide epidemic, with high morbidity and mortality. Cuproptosis
is a form of cell death that is associated with a wide range of diseases. This study aimed to …

Metabolic underpinnings of cancer-related fatigue

X Zhang, RJ Perry - American Journal of Physiology …, 2024 - journals.physiology.org
Cancer-related fatigue (CRF) is one of the most prevalent and detrimental complications of
cancer. Emerging evidence suggests that obesity and insulin resistance are associated with …

Thiazolidinedione enhances the efficacy of anti-PD-1 monoclonal antibody in murine melanoma

X Zhang, Y Gao, K Tang, Z Li… - American Journal …, 2024 - journals.physiology.org
Several clinical studies observed a surprising beneficial effect of obesity on enhancing
immunotherapy responsiveness in patients with melanoma, highlighting an as-yet …

[HTML][HTML] Transcriptomic and Proteomic Insights into Host Immune Responses in Pediatric Severe Malarial Anemia: Dysregulation in HSP60-70-TLR2/4 Signaling and …

CO Onyango, SB Anyona, I Hurwitz, E Raballah… - Pathogens, 2024 - mdpi.com
Severe malarial anemia (SMA, Hb< 6.0 g/dL) is a leading cause of childhood morbidity and
mortality in holoendemic Plasmodium falciparum transmission zones. This study explored …

Dimethyl itaconate restores mitochondrial integrity in LPS-treated C2C12 myoblasts

S Makarova, A Arkhipova, M Nosenko - 2024 - academic.oup.com
Sepsis is an infectious disease affecting billions of individuals worldwide every year. It is
characterized by uncontrolled dissemination of the pathogen as well as deregulated …