Enzymes are very efficient catalysts that are essential for the functioning of living organisms.
The low efficiency of biocatalysts produced de novo relative to those that have evolved …

In enzymes, the active site is the location where incoming substrates are chemically
converted to products. In some enzymes, this site is deeply buried within the core of the …

Tunnels and channels facilitate the transport of small molecules, ions and water solvent in a
large variety of proteins. Characteristics of individual transport pathways, including their …

In 2000, the third member of the globin family was discovered in human and mouse brain
and named neuroglobin (Ngb). Ngb is a monomeric 3/3 globin structurally similar to …

Motivation Protein tunnels and channels are key transport pathways that allow ligands to
pass between proteins' external and internal environments. These functionally important …

Protein structures contain highly complex systems of voids, making up specific features such
as surface clefts or grooves, pockets, protrusions, cavities, pores or channels, and tunnels …

CD95 is a pre-ligand-associated transmembrane (TM) receptor. The interaction with its
ligand CD95L brings to a next level its aggregation and triggers different signaling …

Enzymes exhibit a high degree of specificity for the reactions they catalyze and the
substrates involved in these reactions. The eminent specificity of enzymes inspired the …

Human aromatase (HA), an enzyme located on the membrane of the endoplasmatic
reticulum, is of crucial biological importance in the biosynthesis of estrogens. High levels of …

Human MnSOD is a homotetramer and represents an essential mitochondrial antioxidant
enzyme, which catalyzes the dismutation of superoxide radicals (O2˙−) at near diffusion …