Tailor made: the art of therapeutic mRNA design

M Metkar, CS Pepin, MJ Moore - Nature Reviews Drug Discovery, 2024 - nature.com
Abstract mRNA medicine is a new and rapidly develo** field in which the delivery of
genetic information in the form of mRNA is used to direct therapeutic protein production in …

DNA-Based nonviral gene Therapy─ Challenging but promising

X Guan, Y Pei, J Song - Molecular Pharmaceutics, 2024 - ACS Publications
Over the past decades, significant progress has been made in utilizing nucleic acids,
including DNA and RNA molecules, for therapeutic purposes. For DNA molecules, although …

Analysis of synonymous codon usage patterns in mitochondrial genomes of nine Amanita species

Q Li, Y Luo, A Sha, W **ao, Z **ong, X Chen… - Frontiers in …, 2023 - frontiersin.org
Introduction Codon basis is a common and complex natural phenomenon observed in many
kinds of organisms. Methods In the present study, we analyzed the base bias of 12 …

Intraspecific and interspecific variations in the synonymous codon usage in mitochondrial genomes of 8 pleurotus strains

W Gao, X Chen, J He, A Sha, Y Luo, W **ao, Z **ong… - BMC genomics, 2024 - Springer
In this study, we investigated the codon bias of twelve mitochondrial core protein coding
genes (PCGs) in eight Pleurotus strains, two of which are from the same species. The results …

Harnessing synthetic biology for advancing RNA therapeutics and vaccine design

BA Pfeifer, M Beitelshees, A Hill, J Bassett… - NPJ Systems Biology …, 2023 - nature.com
Recent global events have drawn into focus the diversity of options for combatting disease
across a spectrum of prophylactic and therapeutic approaches. The recent success of the …

Assembly and comparative analysis of the complete multichromosomal mitochondrial genome of Cymbidium ensifolium, an orchid of high economic and ornamental …

B Shen, A Shen, L Liu, Y Tan, S Li, Z Tan - BMC Plant Biology, 2024 - Springer
Background Orchidaceae is one of the largest groups of angiosperms, and most species
have high economic value and scientific research value due to their ornamental and …

Advancing cancer immunotherapy: The potential of mRNA vaccines as a promising therapeutic approach

F Goyal, A Chattopadhyay, U Navik, A Jain… - Advanced …, 2024 - Wiley Online Library
Abstract mRNA vaccines have long been recognized for their ability to induce robust
immune responses. The discovery that mRNA vaccines may also contribute to antitumor …

Personalized mRNA vaccines in glioblastoma therapy: from rational design to clinical trials

I Karimi-Sani, Z Molavi, S Naderi, SH Mirmajidi… - Journal of …, 2024 - Springer
Glioblastomas (GBMs) are the most common and aggressive malignant brain tumors,
presenting significant challenges for treatment due to their invasive nature and localization …

Tobacco as green bioreactor for therapeutic protein production: latest breakthroughs and optimization strategies

M Naeem, R Han, N Ahmad, W Zhao, L Zhao - Plant Growth Regulation, 2024 - Springer
In recent years, higher plants have emerged as intrinsic sources for generating vast
quantities of valuable therapeutic proteins to meet the demands of disease prevention or …

[HTML][HTML] Complete Chloroplast Genomes and Phylogenetic Relationships of Bougainvillea spectabilis and Bougainvillea glabra (Nyctaginaceae)

H Zhang, T Huang, Q Zhou, Q Sheng, Z Zhu - International Journal of …, 2023 - mdpi.com
Bougainvillea L.(Nyctaginaceae) is a South American native woody flowering shrub of high
ornamental, economic, and medicinal value which is susceptible to cold damage. We …