Active pharmaceutical ingredients (APIs) may exist in various solid forms, which can lead to
differences in the intermolecular interactions, affecting the internal energy and enthalpy, and …

Within the pharmaceutical industry, and elsewhere, the screening for new solid forms is a
mandatory exercise for both existing and new chemical entities. This contribution focuses on …

Mechanochemistry is an effective method for the preparation of multicomponent crystal
systems. In the present work, we propose an alternative to the established liquid‐assisted …

Mechanochemistry is considered an alternative attractive greener approach to prepare
diverse molecular compounds and has become an important synthetic tool in different fields …

Cocrystals are homogenous (single-phase) crystalline structures composed by two or more
components in a definite stoichiometric ratio bonded together by noncovalent bonds …

Poor aqueous solubility and low oral bioavailability of an active pharmaceutical ingredient
are the major constraints during the development of new product. Various approaches have …

Design and synthesis of pharmaceutical cocrystals have received great interest in recent
years. Cocrystallization of drug substances offers a tremendous opportunity for the …

We present a first direct measurement of the temperature during milling combined with in
situ Raman spectroscopy monitoring. The data reveal a low temperature increase due to the …

Identifying as many polymorphs as possible for a molecular compound is important in the
design of materials with desired properties. In this paper we demonstrate, using a simple …

Mechanochemistry deals with reactions induced by the input of mechanical energy–for
example by impacts within a vibratory ball mill. The technique has a long history with …