Oligonucleotide-based drugs have received considerable attention for their capacity to
modulate gene expression very specifically and as a consequence they have found …

Micro RNA s (mi RNA s) are a newly recognized class of regulatory genes which repress the
expression of protein‐coding genes. Numerous studies have uncovered a complex role for …

MicroRNAs (miRNAs) play an important role in diverse physiological processes and are
potential therapeutic agents. Synthetic oligonucleotides (ONs) of different chemistries have …

Antisense oligonucleotides and short interfering RNAs (siRNAs) are nucleic acids-targeting
reagents for gene expression modulation that are being developed as drugs for many …

The biological understanding of RNA has evolved since the discovery of catalytic RNAs in
the early 1980s and the establishment of RNA interference (RNAi) in the 1990s. RNA is no …

Over the past three decades, peptide nucleic acids have been employed in numerous
chemical and biological applications. Peptide nucleic acids possess enormous potential …

Sequence-selective recognition of complex RNAs in live cells could find broad applications
in biology, biomedical research, and biotechnology. However, specific recognition of …

Despite the fact that non-viral nucleic acid delivery systems are generally considered to be
less efficient than viral vectors, they have gained much interest in recent years due to their …

Oligonucleotide (ON) drugs, including small interfering RNA (siRNA), microRNA (miRNA)
and antisense oligonucleotides, are promising therapeutic agents. However, their low …

Genetic manipulation is an important facet of synthetic biology but can be complicated by
undesired nuclease degradation. Incorporating non-natural nucleic acids into a gene could …