[HTML][HTML] The role of mitochondria in amyotrophic lateral sclerosis

EF Smith, PJ Shaw, KJ De Vos - Neuroscience letters, 2019 - Elsevier
Mitochondria are unique organelles that are essential for a variety of cellular processes
including energy metabolism, calcium homeostasis, lipid biosynthesis, and apoptosis …

Mitophagy in human diseases

L Doblado, C Lueck, C Rey, AK Samhan-Arias… - International journal of …, 2021 - mdpi.com
Mitophagy is a selective autophagic process, essential for cellular homeostasis, that
eliminates dysfunctional mitochondria. Activated by inner membrane depolarization, it plays …

Mitochondrial fission protein 1: emerging roles in organellar form and function in health and disease

UK Ihenacho, KA Meacham, MC Harwig… - Frontiers in …, 2021 - frontiersin.org
Mitochondrial fission protein 1 (Fis1) was identified in yeast as being essential for
mitochondrial division or fission and subsequently determined to mediate human …

Three-dimensional ultrastructure of giant mitochondria in human non-alcoholic fatty liver disease

GJ Shami, D Cheng, P Verhaegh, G Koek, E Wisse… - Scientific Reports, 2021 - nature.com
Giant mitochondria are peculiarly shaped, extremely large mitochondria in hepatic
parenchymal cells, the internal structure of which is characterised by atypically arranged …

Mitochondrial dysfunction contributes to the pathogenesis of Alzheimer's disease

FA Cabezas-Opazo, K Vergara-Pulgar… - Oxidative medicine …, 2015 - Wiley Online Library
Alzheimer's disease (AD) is a neurodegenerative disease that affects millions of people
worldwide. Currently, there is no effective treatment for AD, which indicates the necessity to …

Mitochondria in disease: changes in shapes and dynamics

BC Jenkins, K Neikirk, P Katti, SM Claypool… - Trends in biochemical …, 2024 - cell.com
Mitochondrial structure often determines the function of these highly dynamic,
multifunctional, eukaryotic organelles, which are essential for maintaining cellular health …

Effect of Ambient PM2.5 on Lung Mitochondrial Damage and Fusion/Fission Gene Expression in Rats

R Li, X Kou, H Geng, J **e, Z Yang… - Chemical research in …, 2015 - ACS Publications
Exposure to ambient fine particulate matter (PM2. 5) increases the risk of respiratory
disease. Although previous mitochondrial research has provided new information about PM …

Mitochondrial dynamic dysfunction as a main triggering factor for inflammation associated chronic non-communicable diseases

Z Geto, MD Molla, F Challa, Y Belay… - Journal of inflammation …, 2020 - Taylor & Francis
Mitochondria are organelles with highly dynamic ultrastructure maintained by flexible fusion
and fission rates governed by Guanosine Triphosphatases (GTPases) dependent proteins …

Increased mitochondrial fusion allows the survival of older animals in diverse C. elegans longevity pathways

SN Chaudhari, ET Kipreos - Nature communications, 2017 - nature.com
Mitochondria are dynamic organelles that undergo fusion and fission events. Mitochondrial
dynamics are required for mitochondrial viability and for responses to changes in …

Mitochondrial morphofunction in mammalian cells

EP Bulthuis, MJW Adjobo-Hermans… - Antioxidants & redox …, 2019 - liebertpub.com
Significance: In addition to their classical role in cellular ATP production, mitochondria are of
key relevance in various (patho) physiological mechanisms including second messenger …