Interleukin-1 is a pro-inflammatory cytokine that has numerous biological effects, including
activation of many inflammatory processes (through activation of T cells, for example) …

Diverse commensal populations are now regarded as key to physiological homeostasis and
protection against disease. Although bacteria are the most abundant component of …

The human host survives many infectious challenges in the absence of preexisting specific
(adaptive) immunity because of the existence of a separate set of protective mechanisms …

The release of IL-1β is a tightly controlled process that requires induced synthesis of the
precursor pro-IL-1β and a second stimulus that initiates cleavage and secretion of mature IL …

The proinflammatory IL-1 cytokines IL-1α, IL-1β, and IL-18 are key mediators of the acute
immune response to injury and infection. Mechanisms underlying their cellular release …

Interleukin-1β (IL-1β) is a potent proinflammatory cytokine that initiates and amplifies a wide
variety of effects associated with innate immunity and host responses to microbial invasion …

The mechanisms underlying caspase-1 activation and IL-1β processing during inflammatory
activation of monocytes and macrophages are not well defined. Here, we describe an in vitro …

Host defence peptides are a conserved component of the innate immune response in all
complex life forms. In humans, the major classes of host defence peptides include the α-and …

The inflammatory process, orchestrated against a variety of injurious stimuli, is composed of
three inter-related phases; initiation, propagation and resolution. Understanding the …

Cathelicidins are a class of gene-encoded antibiotics found exclusively in mammals. In vitro
and in vivo studies indicate they are effector molecules of mammalian innate immunity that …