[HTML][HTML] Osteoblast suppression in multiple myeloma bone disease

J Adamik, DL Galson, GD Roodman - Journal of bone oncology, 2018 - Elsevier
Multiple myeloma (MM) is the most frequent cancer to involve the skeleton with patients
develo** osteolytic bone lesions due to hyperactivation of osteoclasts and suppression of …

Animal models of multiple myeloma bone disease

SH Mehdi, S Nafees, SJ Mehdi, CA Morris… - Frontiers in …, 2021 - frontiersin.org
Multiple myeloma (MM) is a clonal B-cell disorder characterized by the proliferation of
malignant plasma cells (PCs) in the bone marrow, the presence of monoclonal serum …

Tgfβ inhibition stimulates collagen maturation to enhance bone repair and fracture resistance in a murine myeloma model

AC Green, D Lath, K Hudson, B Walkley… - Journal of Bone and …, 2019 - academic.oup.com
Multiple myeloma is a plasma cell malignancy that causes debilitating bone disease and
fractures, in which TGFβ plays a central role. Current treatments do not repair existing …

[HTML][HTML] Panniculitis and pancreatitis: Inflammation and necrotic mechanisms in a patient with alcohol use disorder and alarming suspicion for malignant process

A Mahmoud, I Soliman, B Kania, M Ghrewati… - Radiology Case …, 2023 - Elsevier
Panniculitis is an inflammatory process localized to subcutaneous tissue, with etiologies
including infection, malignancy, external insults, enzymatic destructive processes, and …

Recent Advances in Minimally Invasive Management of Osteolytic Periacetabular Skeletal Metastases

W Jiang, S Lee, D Caruana… - Seminars in …, 2024 - thieme-connect.com
Painful skeletal osteolytic metastases, impending pathological fractures, and nondisplaced
fractures present as a devastating clinical problem in advanced stage cancer patients. Open …

The Synthetic Collagen-Binding Peptide NIPEP-OSS Delays Mouse Myeloma Progression

SH Mehdi, AC Gentry, JY Lee, CP Chung, D Yoon - Cancers, 2023 - mdpi.com
Simple Summary Multiple myeloma is a plasma cell cancer with bone destruction and is still
considered an incurable disease despite advancements in its treatment. Over 90% of …

[HTML][HTML] Assessing osteolytic lesion size on sequential CT scans is a reliable study endpoint for bone remineralization in newly diagnosed multiple myeloma

JP Grunz, AS Kunz, FT Baumann, D Hasenclever… - Cancers, 2023 - mdpi.com
Simple Summary While MRI is primarily used for vitality analysis in multiple myeloma, the
detection of osteolytic manifestations in the mineralized bone is performed on CT scans. For …

Bone remineralization of lytic lesions in multiple myeloma–The Arkansas experience

M Mohan, M Kumar, R Samant, R Van Hemert Jr… - Bone, 2021 - Elsevier
Multiple myeloma (MM) patients frequently present with extensive osteolytic bone lesions.
However, the impact of myeloma treatment on focal lytic lesion remineralization has not …

[PDF][PDF] Assessment of Bone Disease in Multiple Myeloma Patients After Autologous Stem Cell Transplant

F Flaih, A Alkudary - Annals of the College of Medicine Mosul, 2022 - iasj.net
Background: Detection of lytic bone lesions is crucial in the workup for multiple myeloma
(MM) and very often dictates the decision to start treatment. Modern imaging techniques …

Impact of MGUS and myeloma on skeletal health

GD Roodman, MT Drake - Marcus and Feldman's Osteoporosis, 2021 - Elsevier
Multiple myeloma (MM) is an incurable plasma cell malignancy that evolves from a
premalignant condition termed monoclonal gammopathy of undetermined significance …