Noncanonical NF-κB signaling differs from canonical NF-κB signaling by being activated
through different cell surface receptors, cytoplasmic adaptors, and NF-κB dimers. Under …

The mammalian Rel/NF-κB family of transcription factors, including RelA, c-Rel, RelB, NF-
κB1 (p50 and its precursor p105), and NF-κB2 (p52 and its precursor p100), plays a central …

To replicate their genomes in cells and generate new progeny, viruses typically require
factors provided by the cells that they have infected. Subversion of the cellular machinery …

Hepatocellular carcinoma (HCC) is the third cancer killer worldwide with> 600,000 deaths
every year. Although the major risk factors are known, therapeutic options in patients remain …

In the early 1990'sa group of unrelated genes were identified from the sites of recurring
translocations in B-cell lymphomas. Despite sharing the nomenclature 'Bcl', and an …

Despite the existence of effective vaccines, HBV infection remains a major health problem
with 2 billion people infected worldwide. Among them, 350 million are chronically infected, a …

As cellular models for in vitro liver cancer and toxicity studies, HepG2 and Hep3B are the
two most frequently used liver cancer cell lines. Because of their similarities they are often …

Abstract DNA methyltransferase 1 (DNMT1) is responsible for copying DNA methylation
patterns to the daughter strands during DNA replication. Its expression is frequently up …

Hepatocellular carcinoma (HCC) is well known for poor prognosis and short survival
because of high recurrence rate even after curative surgery. Today there is no available …

Mitochondria are highly dynamic and undergo constant fusion and fission that are essential
for maintaining physiological functions of cells. Recently, we have reported that increased …