The traditional two-dimensional (2D) in vitro cell culture system (on a flat support) has long
been used in cancer research. However, this system cannot be fully translated into clinical …

Three‐dimensional cell culture models, such as spheroids, can be used in the process of the
development of new anticancer agents because they are able to closely mimic the main …

Most cancer biologists still rely on conventional two-dimensional (2D) monolayer culture
techniques to test in vitro anti-tumor drugs prior to in vivo testing. However, the vast majority …

Nanomedicine has been extensively explored to enhance the efficacy of chemotherapy with
modest therapeutic efficacy in the clinic, owing to various factors. A primary factor is …

Cytosolic protein delivery is of central importance for the development of protein-based
biotechnologies and therapeutics; however, efficient intracellular delivery of native proteins …

In vivo screening of phage libraries in tumor-bearing mice has been used to identify
peptides that direct phage homing to a tumor. The power of in vivo phage screening is …

Cytosolic protein delivery offers opportunities to develop protein-based therapeutics
specifically modulate intracellular processes, especially those linked to 'undruggable'targets …

Development of hydrogel-based flexible electronics with robust elasticity, low hysteresis,
and excellent durability is still challenging. Herein, for the first time, B–N coordination was …

Three dimensional multicellular aggregate, also referred to as cell spheroid or microtissue,
is an indispensable tool for in vitro evaluating antitumor activity and drug efficacy. Compared …

Highly sensitive and specific non-invasive molecular imaging methods are particularly
desirable for the early detection of cancers. Here we report a near-infrared optical imaging …