The anticancer therapeutic potential of pyrimidine–sulfonamide hybrids
P Zhang, C Shi, T Dong, J Song… - Future Medicinal Chemistry, 2024 - Taylor & Francis
Cancer as a devastating malignancy, seriously threatens human life and health, but most
chemotherapeutics have long been criticized for unsatisfactory therapeutic efficacy due to …
chemotherapeutics have long been criticized for unsatisfactory therapeutic efficacy due to …
Synthesis and in vitro antitumor evaluation of new thieno [2, 3-d] pyrimidine derivatives as EGFR and DHFR inhibitors
New thienopyrimidine derivatives 2–16 have been synthesized and their in vitro cytotoxicity
was evaluated against five different human cancer cell lines HCT-116, Hela, MDA-MB-231 …
was evaluated against five different human cancer cell lines HCT-116, Hela, MDA-MB-231 …
Antimicrobial Evaluation of Sulfonamides after Coupling with Thienopyrimidine Coplanar Structure
EI Elmongy, WS Alanazi, AI Aldawsari, AA Alfaouri… - Pharmaceuticals, 2024 - mdpi.com
This work describes the design and synthesis of three series of hybrids of thienopyrimidines
and sulfonamides. Dihydrofolate reductase enzyme was selected as a target for the in-silico …
and sulfonamides. Dihydrofolate reductase enzyme was selected as a target for the in-silico …
[HTML][HTML] In Silico and In Vitro Investigation of Cytotoxicity and Apoptosis of Acridine/Sulfonamide Hybrids Targeting Topoisomerases I and II
Background: Sulfonamide acridine derivatives have garnered significant attention from
medicinal chemists due to their diverse range of biological activities. Methods: In this study …
medicinal chemists due to their diverse range of biological activities. Methods: In this study …
[PDF][PDF] Synthesis, in silico and in vitro antimicrobial activity of N-(benzyl)-5-methyl-4-oxo-3, 4-dihydrothieno [2, 3-d] pyrimidine-6-carboxamides
SV Vlasov, OV Borysov, HI Severina, VS Vlasov… - …, 2024 - pharmacia.pensoft.net
According to the recent studies bezylcarboxamide fragment attached to the thiophene ring of
thieno [2, 3-d] pyrimidine is beneficial for antimicrobial activity of the compounds. Therefore …
thieno [2, 3-d] pyrimidine is beneficial for antimicrobial activity of the compounds. Therefore …