The S100 proteins, a family of calcium-binding cytosolic proteins, have a broad range of
intracellular and extracellular functions through regulating calcium balance, cell apoptosis …

Our immune system is based on the close collaboration of the innate and adaptive immune
systems for the rapid detection of any threats to the host. Recognition of pathogen-derived …

Down Syndrome (DS) entails an increased risk of many chronic diseases that are typically
associated with older age. The clinical manifestations of accelerated aging suggest that …

S100 proteins are calcium-binding proteins that regulate several processes associated with
Alzheimer's disease (AD) but whose contribution and direct involvement in disease …

Aquaporin-4 (AQP4) is the main water channel protein expressed in the central nervous
system (CNS). AQP4 is densely expressed in astrocyte end-feet, and is an important factor in …

The Ca2+-binding protein of the EF-hand type, S100B, exerts both intracellular and
extracellular functions. Recent studies have provided more detailed information concerning …

Trisomy 21 is the most frequent genetic cause of cognitive impairment. To assess the
perturbations of gene expression in trisomy 21, and to eliminate the noise of genomic …

J. Neurochem.(2012) 120, 644–659. Abstract S100B is a calcium‐binding protein
concentrated in glial cells, although it has also been detected in definite extra‐neural cell …

The availability of the human genome sequence has allowed identification of disease-
causing mutations in many Mendelian disorders, and detection of significant associations of …

Abstract Down's syndrome (DS), caused by trisomy of human chromosome 21, is the most
common genetic cause of intellectual disability. Here we use induced pluripotent stem cells …