Inspired by the success of fluorinated corticosteroids in the 1950s and fluoroquinolones in
the 1980s, fluorine-containing pharmaceuticals, which are also known as fluoro …

This Perspective surveys the progress and current limitations of nucleophilic fluorination
methodologies. Despite the long and rich history of C (sp3)–F bond construction in chemical …

The elaboration of step-economy and catalytic approaches for accessing diverse fluorinated
heterocyclics is highly desirable. Described herein is a radical-polar crossover enabled …

Nine new fluorine-containing drugs have been approved by the US Food and Drug
Administration (FDA) in 2021, which are presented in this review article. These small …

The hydrofluorination of alkenes represents an attractive strategy for the synthesis of
aliphatic fluorides. This approach provides a direct means to form C (sp3)–F bonds …

The synthesis of organic compounds efficiently via fewer steps but in higher yields is
desirable as this reduces energy and reagent use, waste production, and thus …

Directly utilizing abundant and inexpensive sources of aliphatic carboxylic acids is highly
attractive for the synthesis of CF2H-and CH3-containing compounds. Herein, we report a …

Fluoroorganic chemistry has become essential in the evolution of many different but
interconnected research fields. These include the development of new materials with a …

Fluorine compounds are known for their abundance in more than 20% of pharmaceutical
and agrochemical products mainly due to the enhanced lipophilicity, metabolic stability and …

Fluorine is characterized by high electronegativity and small atomic size, which provide this
molecule with the unique property of augmenting the potency, selectivity, metabolic stability …