Molecular Understanding of ACE-2 and HLA-conferred differential susceptibility to COVID-19: host-directed insights opening new windows in COVID-19 Therapeutics

IU Haq, K Krukiewicz, H Tayyab, I Khan… - Journal of Clinical …, 2023 - mdpi.com
The genetic variants of HLAs (human leukocyte antigens) play a crucial role in the virus–
host interaction and pathology of COVID-19. The genetic variants of HLAs not only influence …

Diagnostic work‐up for severe aplastic anemia in children: consensus of the North American Pediatric Aplastic Anemia Consortium

KA Shimano, A Narla, MJ Rose… - American journal of …, 2021 - Wiley Online Library
Abstract The North American Pediatric Aplastic Anemia Consortium (NAPAAC) is a group of
pediatric hematologist‐oncologists, hematopathologists, and bone marrow transplant …

Molecular landscape of immune pressure and escape in aplastic anemia

S Pagliuca, C Gurnari, C Hercus, S Hergalant… - Leukemia, 2023 - nature.com
Idiopathic aplastic anemia (IAA) pathophysiology is dominated by autoreactivity of human
leukocyte antigen (HLA)-restricted T-cells against antigens presented by hematopoietic stem …

Genetic testing in severe aplastic anemia is required for optimal hematopoietic cell transplant outcomes

LJ McReynolds, M Rafati, Y Wang… - Blood, The Journal …, 2022 - ashpublications.org
Patients with severe aplastic anemia (SAA) can have an unrecognized inherited bone
marrow failure syndrome (IBMFS) because of phenotypic heterogeneity. We curated …

Leukemia relapse via genetic immune escape after allogeneic hematopoietic cell transplantation

S Pagliuca, C Gurnari, C Hercus, S Hergalant… - Nature …, 2023 - nature.com
Abstract Graft-versus-leukemia (GvL) reactions are responsible for the effectiveness of
allogeneic hematopoietic cell transplantation as a treatment modality for myeloid neoplasia …

The similarity of class II HLA genotypes defines patterns of autoreactivity in idiopathic bone marrow failure disorders

S Pagliuca, C Gurnari, H Awada… - Blood, The Journal …, 2021 - ashpublications.org
Idiopathic aplastic anemia (IAA) is a rare autoimmune bone marrow failure (BMF) disorder
initiated by a human leukocyte antigen (HLA)-restricted T-cell response to unknown …

HLA associations, somatic loss of HLA expression, and clinical outcomes in immune aplastic anemia

Y Zaimoku, BA Patel, SD Adams… - Blood, The Journal …, 2021 - ashpublications.org
Immune aplastic anemia (AA) features somatic loss of HLA class I allele expression on bone
marrow cells, consistent with a mechanism of escape from T-cell–mediated destruction of …

Clonal evolution in aplastic anemia: failed tumor surveillance or maladaptive recovery?

C Gurnari, S Pagliuca, JP Maciejewski - Leukemia & Lymphoma, 2023 - Taylor & Francis
Clonal evolution to secondary paroxysmal nocturnal hemoglobinuria (PNH) or myeloid
neoplasia (MN) represents one of the long-term complications of patients with aplastic …

Modified Delphi panel consensus recommendations for management of severe aplastic anemia

DV Babushok, AE DeZern, CM de Castro… - Blood …, 2024 - ashpublications.org
Severe aplastic anemia (SAA) is a rare hematologic condition for which there is no clear
management algorithm. A panel of 11 experts on adult and pediatric aplastic anemia was …

Human leukocyte antigen association study reveals DRB1* 04: 02 effects additional to DRB1* 07: 01 in anti-LGI1 encephalitis

V Peris Sempere, S Muñiz-Castrillo… - Neurology …, 2022 - AAN Enterprises
Background and Objectives To study human leukocyte antigen (HLA) allele associations in
anti-leucine–rich glioma-inactivated 1 (LGI1) encephalitis. Methods A multiethnic cohort of …