Copper is an essential element in cells; it can act as either a recipient or a donor of
electrons, participating in various reactions. However, an excess of copper ions in cells is …

Disturbances in copper (Cu) homeostasis have been observed in diabetes and associated
complications. Cu is an essential micronutrient that plays important roles in various …

Chronic kidney disease (CKD) has become a global public health problem with high
morbidity and mortality. Renal fibrosis can lead to end-stage renal disease (ESRD) …

Copper (Cu) is an essential micronutrient but excess Cu is potentially toxic. Its important
propensity to cycle between two oxidation states accounts for its frequent presence as a …

Copper is a fundamental element for the homeostasis of the body. It is the third most
abundant essential transition metal in humans. Changes in the concentration of copper in …

Copper is a required metal nutrient for life, but global or local alterations in its homeostasis
are linked to diseases spanning genetic and metabolic disorders to cancer and …

Cuproptosis has recently been identified as a novel regulatory mechanism of cell death. It is
characterized by the accumulation of copper in mitochondria and its binding to acylated …

Trace metal elements are of vital importance for fundamental biological processes. They
function in various metabolic pathways after the long evolution of living organisms. Glucose …

Copper is an essential trace metal for normal cellular functions; a lack of copper is reported
to impair the function of important copper‐binding enzymes, while excess copper could lead …

Studies have shown that ursolic acid (UA) and empagliflozin (EM) exert therapeutic effects in
the treatment of diabetic nephropathy (DN), but both drugs have disadvantages. This study …