The Warburg effect on radioresistance: Survival beyond growth

H Kang, B Kim, J Park, HS Youn, BH Youn - Biochimica et Biophysica Acta …, 2023 - Elsevier
The Warburg effect is a phenomenon in which cancer cells rely primarily on glycolysis rather
than oxidative phosphorylation, even in the presence of oxygen. Although evidence of its …

Cytokines secreted by inflamed oral mucosa: implications for oral cancer progression

EB Danella, M Costa de Medeiros, NJ D'Silva - Oncogene, 2023 - nature.com
The oral mucosa has an essential role in protecting against physical, microbial, and
chemical harm. Compromise of this barrier triggers a wound healing response. Key events …

DCZ0415, a small‐molecule inhibitor targeting TRIP13, inhibits EMT and metastasis via inactivation of the FGFR4/STAT3 axis and the Wnt/β‐catenin pathway in …

S Agarwal, F Afaq, P Bajpai, HG Kim… - Molecular …, 2022 - Wiley Online Library
Thyroid receptor‐interacting protein 13 (TRIP13), a protein of the AAA‐ATPase family, is
upregulated in various human cancers, including colorectal cancer (CRC). This study …

TRIP13 regulates progression of gastric cancer through stabilising the expression of DDX21

G Zhang, R Yang, B Wang, Q Yan, P Zhao… - Cell Death & …, 2024 - nature.com
GC (Gastric cancer) is one of the most common malignant tumours, with over 95% of gastric
cancer patients being adenocarcinoma and most gastric cancer patients having no apparent …

[HTML][HTML] Targeting of oncogenic AAA-ATPase TRIP13 reduces progression of pancreatic ductal adenocarcinoma

F Afaq, S Agarwal, P Bajpai, S Al Diffalha, HG Kim… - Neoplasia, 2024 - Elsevier
Thyroid hormone receptor-interacting protein 13 (TRIP13) is involved in cancer progression,
but its role in pancreatic ductal adenocarcinoma (PDAC) is unknown. Thus, we assessed the …

TRIP13 overexpression promotes gefitinib resistance in non‑small cell lung cancer via regulating autophagy and phosphorylation of the EGFR signaling pathway

Z **ao, M Li, X Zhang, X Rong… - Oncology Reports, 2023 - spandidos-publications.com
Non-small cell lung cancer (NSCLC) accounts for the majority of lung cancers and remains
the most common cause of cancer-related death. Epidermal growth factor receptor (EGFR) …

Decoding the research landscape of drug resistance and therapeutic approaches in head and neck cancer: a bibliometric analysis from 2000 to 2023

Q Han, J Shi, J Liu, Y Fu, Z Li, H Guo, X Guan… - Frontiers in …, 2024 - frontiersin.org
Introduction: Head and neck cancer is one of the most common tumors worldwide. However,
drug resistance in its treatment has become a major factor limiting the efficacy. This study …

A plant nonenveloped double-stranded RNA virus activates and co-opts BNIP3-mediated mitophagy to promote persistent infection in its insect vector

Q Liang, J Wan, H Liu, D Jia, Q Chen, A Wang, T Wei - Autophagy, 2023 - Taylor & Francis
Mitophagy that selectively eliminates damaged mitochondria is an essential mitochondrial
quality control mechanism. Recently, mitophagy has been shown to be induced in host cells …

FAM64A promotes HNSCC tumorigenesis by mediating transcriptional autoregulation of FOXM1

X Zhao, H Chen, Y Qiu, L Cui - International Journal of Oral Science, 2022 - nature.com
Head and neck squamous cell carcinoma (HNSCC) still lacks effective targeted treatment.
Therefore, exploring novel and robust molecular targets is critical for improving the clinical …

TRIP13 plays an important role in the sensitivity of leukemia cell response to sulforaphane therapy

L Liu, B Liao, R Fan, Y Liu, A Li, L Liu, Y Li, J Li - ACS omega, 2024 - ACS Publications
Sulforaphane is one of the most characterized isothiocyanate compounds in cruciferous
vegetables and shows anticancer effects, especially antileukemia properties. However, the …