Healthy articular cartilage, covering the ends of bones in major joints such as hips and
knees, presents the most efficiently‐lubricated surface known in nature, with friction …

Chronic, low-grade inflammation in osteoarthritis (OA) contributes to symptoms and disease
progression. Effective disease-modifying OA therapies are lacking, but better understanding …

The major synovial joints such as hips and knees are uniquely efficient tribological systems,
able to articulate over a wide range of shear rates with a friction coefficient between the …

The field of regenerative medicine aims to replace tissues lost as a consequence of disease,
trauma or congenital abnormalities. Biomaterials serve as scaffolds for regenerative …

Articular cartilage is a physiologically non-self-renewing avascular tissue with a singular cell
type, the chondrocyte, which functions as the load-bearing surface of the arthrodial joint …

Chondrogenesis occurs as a result of mesenchymal cell condensation and
chondroprogenitor cell differentiation. Following chondrogenesis, the chondrocytes remain …

Lubricin is a surface-active mucinous glycoprotein secreted in the synovial joint that plays an
important role in cartilage integrity. In healthy joints, lubricin molecules coat the cartilage …

OBJECTIVE: During the development of disease-modifying osteoarthritis (OA) drugs, rat
models of OA are frequently used for a first assessment of in vivo efficacy. The most …

Osteoarthritis (OA) is a widespread joint disease for which there are no disease-modifying
treatments. Previously, we found that mice with cartilage-specific epidermal growth factor …

Mucins are large glycoproteins that are ubiquitous in the animal kingdom. Mucins coat the
surfaces of many cell types and can be secreted to form mucus gels that assume important …