Alzheimer's disease (AD) is an age‐associated neurodegenerative disorder with
multifactorial etiology, intersecting genetic and environmental risk factors, and a lack of …

In a diabetic milieu high levels of reactive oxygen species (ROS) are induced. This
contributes to the vascular complications of diabetes. Recent studies have shown that ROS …

Metabolic dysfunction-associated steatotic liver disease (MASLD) closely associates with
obesity and type 2 diabetes. Lifestyle intervention and bariatric surgery aiming at substantial …

Type 2 diabetes is caused by insulin resistance coupled with an inability to produce enough
insulin to control blood glucose, and thiazolidinediones (TZDs) are the only current …

Peroxisome proliferator-activated receptors (PPARs) compose a family of three nuclear
receptors which act as lipid sensors to modulate gene expression. As such, PPARs are …

Generation and deposition of amyloid beta peptides and neurofibrillary tangle formation are
key mechanisms involved in AD pathogenesis. Recent evidence suggests that inflammatory …

Generation of neurotoxic amyloid β peptides and their deposition along with neurofibrillary
tangle formation represent key pathological hallmarks in Alzheimer's disease (AD). Recent …

Facilitated pyruvate transport across the mitochondrial inner membrane is a critical step in
carbohydrate, amino acid, and lipid metabolism. We report that clinically relevant …

The biology of peroxisome proliferator activated receptors (PPARs) in physiological and
pathophysiological processes has been primarily studied in peripherial organs and tissues …

Identification of G protein-coupled receptors that are activated by free fatty acids has led to
considerable interest in their pharmacology and function because of the wide range of …