Redefining critical illness

DM Maslove, B Tang, M Shankar-Hari, PR Lawler… - Nature medicine, 2022 - nature.com
Research and practice in critical care medicine have long been defined by syndromes,
which, despite being clinically recognizable entities, are, in fact, loose amalgams of …

Acute respiratory distress syndrome

MA Matthay, RL Zemans, GA Zimmerman… - Nature reviews Disease …, 2019 - nature.com
The acute respiratory distress syndrome (ARDS) is a common cause of respiratory failure in
critically ill patients and is defined by the acute onset of noncardiogenic pulmonary oedema …

The Japanese clinical practice guidelines for management of sepsis and septic shock 2020 (J-SSCG 2020)

M Egi, H Ogura, T Yatabe, K Atagi, S Inoue, T Iba… - Journal of intensive …, 2021 - Springer
Abstract The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic
Shock 2020 (J-SSCG 2020), a Japanese-specific set of clinical practice guidelines for sepsis …

Mechanical ventilation in patients with acute brain injury: recommendations of the European Society of Intensive Care Medicine consensus

C Robba, D Poole, M McNett, K Asehnoune… - Intensive care …, 2020 - Springer
Purpose To provide clinical practice recommendations and generate a research agenda on
mechanical ventilation and respiratory support in patients with acute brain injury (ABI) …

Perioperative pulmonary atelectasis-part II: clinical implications

D Lagier, C Zeng, A Fernandez-Bustamante… - …, 2022 - pmc.ncbi.nlm.nih.gov
The development of pulmonary atelectasis is common in the surgical patient. Pulmonary
atelectasis can cause various degrees of gas exchange and respiratory mechanics …

Time-varying intensity of mechanical ventilation and mortality in patients with acute respiratory failure: a registry-based, prospective cohort study

M Urner, P Jüni, B Hansen, MS Wettstein… - The Lancet …, 2020 - thelancet.com
Background Mortality in acute respiratory failure remains high despite the use of lung-
protective ventilation. Recent studies have shown an association between baseline …

Pulse oximetry for the diagnosis and management of acute respiratory distress syndrome

KD Wick, MA Matthay, LB Ware - The Lancet Respiratory Medicine, 2022 - thelancet.com
The diagnosis of acute respiratory distress syndrome (ARDS) traditionally requires
calculation of the ratio of partial pressure of arterial oxygen to fraction of inspired oxygen …

Predictors of pneumothorax/pneumomediastinum in mechanically ventilated COVID-19 patients

A Belletti, D Palumbo, A Zangrillo, EV Fominskiy… - Journal of cardiothoracic …, 2021 - Elsevier
Objective To determine the incidence, predictors, and outcome of pneumothorax (PNX)/
pneumomediastinum (PMD) in coronavirus disease 2019 (COVID-19) acute respiratory …

Brain–lung interactions and mechanical ventilation in patients with isolated brain injury

M Ziaka, A Exadaktylos - Critical care, 2021 - Springer
During the last decade, experimental and clinical studies have demonstrated that isolated
acute brain injury (ABI) may cause severe dysfunction of peripheral extracranial organs and …

Development and validation of a reinforcement learning algorithm to dynamically optimize mechanical ventilation in critical care

A Peine, A Hallawa, J Bickenbach, G Dartmann… - NPJ digital …, 2021 - nature.com
The aim of this work was to develop and evaluate the reinforcement learning algorithm
VentAI, which is able to suggest a dynamically optimized mechanical ventilation regime for …