Acetylcholine (ACh) has a crucial role in the peripheral and central nervous systems. The
enzyme choline acetyltransferase (ChAT) is responsible for synthesizing ACh from acetyl …

Acetylcholine is one of the major modulators of brain functions and it is the main
neurotransmitter at the peripheral nervous system. Modulation of acetylcholine release is …

Invasion of the nervous system and neuronal spread of infection are critical, but poorly
understood, steps in the pathogenesis of transmissible spongiform encephalopathies or …

Rho GTPases regulate the actin cytoskeleton, exocytosis, endocytosis, and other signaling
cascades. Rhos are subdivided into four subfamilies designated Rho, Racs, Cdc42, and a …

Vesicular monoamine transporters (VMATs) mediate the transport of dopamine (DA),
serotonin (5HT), and other monoamines into secretory vesicles. The regulation of …

The secreted cochaperone STI1 triggers activation of protein kinase A (PKA) and ERK1/2
signaling by interacting with the cellular prion (PrPC) at the cell surface, resulting in …

The release of intercellular messengers from synaptic (SVs) and dense-core vesicles
(DCVs) constitutes the primary mechanism for communication between neighboring or …

We have investigated the intracellular traffic of PrP c, a glycosylphosphatidylinositol (GPI)-
anchored protein implicated in spongiform encephalopathies. A fluorescent functional green …

Expression of the integral and associated proteins of synaptic vesicles is subject to
regulation over time, by region, and in response to activity. The process by which changes in …

Maintenance of acetylcholine (ACh) synthesis depends on the activity of the high‐affinity
choline transporter (CHT1), which is responsible for the reuptake of choline from the …