Importance A 2016 review for the US Preventive Services Task Force (USPSTF) found use
of statins for primary prevention of cardiovascular disease (CVD) was associated with …

Background: High-sensitivity assays can quantify cardiac troponins I and T (hs-cTnI, hs-
cTnT) in individuals with no clinically manifest myocardial injury. Objectives: The goal of this …

Risk stratification is critical for the early identification of high-risk individuals and disease
prevention. Here we explored the potential of nuclear magnetic resonance (NMR) …

Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown.
We conducted a multiancestry genome-wide-association meta-analysis in 521,612 …

General cognitive function is a prominent and relatively stable human trait that is associated
with many important life outcomes. We combine cognitive and genetic data from the …

Background Overweight and obesity are increasing worldwide. To help assess their
relevance to mortality in different populations we conducted individual-participant data meta …

Background: Heart failure (HF) is a highly prevalent disorder for which disease mechanisms
are incompletely understood. The discovery of disease-associated proteins with causal …

Reduced glomerular filtration rate defines chronic kidney disease and is associated with
cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide …

Background Statins increase the risk of new-onset type 2 diabetes mellitus. We aimed to
assess whether this increase in risk is a consequence of inhibition of 3-hydroxy-3 …

Background Uncertainties persist about the magnitude of associations of diabetes mellitus
and fasting glucose concentration with risk of coronary heart disease and major stroke …