Tissue and cellular milieux have microscopically fragmented aqueous compartments
separated by vesiculated membranes. Roughly one-half of the protein in cells is estimated to …

Interfacial enzymes operate at an organized interface such as lipid aggregates in contact
with the aqueous phase. The enzyme phospholipase A2 is a well studied interfacial enzyme …

Several water-soluble enzymes act on their amphipathic substrates in biological membranes
and related interfaces such as emulsions, micelles, monolayers and bilayers, For example …

Mammalian secreted phospholipases A 2 (sPLA2s) comprise a group of at least eight
enzymes, including the recently identified group X sPLA2. A bacterial expression system …

A standing hypothesis in membrane biology implies that the collective physical properties of
the lipid bilayer component of biological membranes can modulate the activity of membrane …

The regulation of phospholipase A 2 (PLA 2) activity toward synthetic vesicular substrates is
a model for the modulation of enzyme function by biological membranes. PLA 2's catalytic …

(1) Introduction Enzymes acting on aggregates or surfaces sometimes display complex
kinetic behavior that is difficult to interpret quan-titatively. Often this is due to the difficulty of …

The interplay between molecular self-organization and molecular recognition leads to the
construction of functional supramolecular systems in which order and mobility are combined …

Interfacial catalysis is a necessary consequence for all enzymes that act on amphipathic
substrates with a strong tendency to form aggregates in aqueous dispersions. In such cases …

Abstract Phospholipase A 2 (PLA 2) hydrolyzes phospholipids to free fatty acids and
lysolipids and thus initiates the biosynthesis of eicosanoids and platelet-activating factor …