Peptidomimetics: an overview of recent medicinal chemistry efforts toward the discovery of novel small molecule inhibitors

G Li Petri, S Di Martino, M De Rosa - Journal of Medicinal …, 2022 - ACS Publications
The use of peptides as therapeutics has often been associated with several drawbacks such
as poor absorption, low stability to proteolytic digestion, and fast clearance. Peptidomimetics …

Site-specific dual encoding and labeling of proteins via genetic code expansion

RM Bednar, PA Karplus, RA Mehl - Cell chemical biology, 2023 - cell.com
The ability to selectively modify proteins at two or more defined locations opens new
avenues for manipulating, engineering, and studying living systems. As a chemical biology …

A Patent Review on SARS Coronavirus Main Protease (3CLpro) Inhibitors

CSB Chia, W Xu, P Shuyi Ng - ChemMedChem, 2022 - Wiley Online Library
The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) pandemic is an
unprecedented global health emergency causing more than 4.2 million fatalities as of 30 …

Sulfur-containing peptides: Synthesis and application in the discovery of potential drug candidates

Y Liao, M Wang, X Jiang - Current Opinion in Chemical Biology, 2023 - Elsevier
Peptides act as biological mediators and play a key role of various physiological activities.
Sulfur-containing peptides are widely used in natural products and drug molecules due to …

Synthesis of disulfide surrogate peptides incorporating large‐span surrogate bridges through a native‐chemical‐ligation‐assisted diaminodiacid strategy

Q Qu, S Gao, F Wu, MG Zhang, Y Li… - Angewandte …, 2020 - Wiley Online Library
The use of synthetic bridges as surrogates for disulfide bonds has emerged as a practical
strategy to obviate the poor stability of some disulfide‐containing peptides. However …

Preparation and characterization of novel epoxy Vitrimer asphalt binders based on reversible covalent network

Y Wang, X Yan, T Ai, C Wang, Y Zhang, S Jiang… - … and Building Materials, 2024 - Elsevier
Although epoxy asphalt possesses excellent mechanical properties, good fatigue
resistance, and high durability, it is not recyclable. The aim of this study is to apply the …

De novo design and directed folding of disulfide-bridged peptide heterodimers

S Yao, A Moyer, Y Zheng, Y Shen, X Meng… - Nature …, 2022 - nature.com
Peptide heterodimers are prevalent in nature, which are not only functional macromolecules
but molecular tools for chemical and synthetic biology. Computational methods have also …

Recent Developments in the Ruthenium‐Catalyzed Azide Alkyne Cycloaddition (RuAAC) Reaction

F Ferrara, T Beke‐Somfai… - European Journal of …, 2024 - Wiley Online Library
The ruthenium‐catalyzed azide‐alkyne cycloaddition (RuAAC) gives access to 1, 5‐
disubstitued triazoles in a single atom‐economical step and offers advantages compared to …

Base-controlled Fe (Pc)-catalyzed aerobic oxidation of thiols for the synthesis of S–S and S–P (O) bonds

H Huang, J Ash, JY Kang - Organic & Biomolecular Chemistry, 2018 - pubs.rsc.org
Fe (Pc)-Catalyzed aerobic oxidation of thiols for the synthesis of disulfides has been
developed under mild reaction conditions. In addition, an aerobic oxidative cross …

Application and Structural Analysis of Triazole‐Bridged Disulfide Mimetics in Cyclic Peptides

AM White, SJ de Veer, G Wu, PJ Harvey… - Angewandte …, 2020 - Wiley Online Library
Ruthenium‐catalysed azide–alkyne cycloaddition (RuAAC) provides access to 1, 5‐
disubstituted 1, 2, 3‐triazole motifs in peptide engineering applications. However …