Peptidomimetics: an overview of recent medicinal chemistry efforts toward the discovery of novel small molecule inhibitors
G Li Petri, S Di Martino, M De Rosa - Journal of Medicinal …, 2022 - ACS Publications
The use of peptides as therapeutics has often been associated with several drawbacks such
as poor absorption, low stability to proteolytic digestion, and fast clearance. Peptidomimetics …
as poor absorption, low stability to proteolytic digestion, and fast clearance. Peptidomimetics …
Site-specific dual encoding and labeling of proteins via genetic code expansion
The ability to selectively modify proteins at two or more defined locations opens new
avenues for manipulating, engineering, and studying living systems. As a chemical biology …
avenues for manipulating, engineering, and studying living systems. As a chemical biology …
A Patent Review on SARS Coronavirus Main Protease (3CLpro) Inhibitors
CSB Chia, W Xu, P Shuyi Ng - ChemMedChem, 2022 - Wiley Online Library
The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) pandemic is an
unprecedented global health emergency causing more than 4.2 million fatalities as of 30 …
unprecedented global health emergency causing more than 4.2 million fatalities as of 30 …
Sulfur-containing peptides: Synthesis and application in the discovery of potential drug candidates
Y Liao, M Wang, X Jiang - Current Opinion in Chemical Biology, 2023 - Elsevier
Peptides act as biological mediators and play a key role of various physiological activities.
Sulfur-containing peptides are widely used in natural products and drug molecules due to …
Sulfur-containing peptides are widely used in natural products and drug molecules due to …
Synthesis of disulfide surrogate peptides incorporating large‐span surrogate bridges through a native‐chemical‐ligation‐assisted diaminodiacid strategy
Q Qu, S Gao, F Wu, MG Zhang, Y Li… - Angewandte …, 2020 - Wiley Online Library
The use of synthetic bridges as surrogates for disulfide bonds has emerged as a practical
strategy to obviate the poor stability of some disulfide‐containing peptides. However …
strategy to obviate the poor stability of some disulfide‐containing peptides. However …
Preparation and characterization of novel epoxy Vitrimer asphalt binders based on reversible covalent network
Y Wang, X Yan, T Ai, C Wang, Y Zhang, S Jiang… - … and Building Materials, 2024 - Elsevier
Although epoxy asphalt possesses excellent mechanical properties, good fatigue
resistance, and high durability, it is not recyclable. The aim of this study is to apply the …
resistance, and high durability, it is not recyclable. The aim of this study is to apply the …
De novo design and directed folding of disulfide-bridged peptide heterodimers
S Yao, A Moyer, Y Zheng, Y Shen, X Meng… - Nature …, 2022 - nature.com
Peptide heterodimers are prevalent in nature, which are not only functional macromolecules
but molecular tools for chemical and synthetic biology. Computational methods have also …
but molecular tools for chemical and synthetic biology. Computational methods have also …
Recent Developments in the Ruthenium‐Catalyzed Azide Alkyne Cycloaddition (RuAAC) Reaction
F Ferrara, T Beke‐Somfai… - European Journal of …, 2024 - Wiley Online Library
The ruthenium‐catalyzed azide‐alkyne cycloaddition (RuAAC) gives access to 1, 5‐
disubstitued triazoles in a single atom‐economical step and offers advantages compared to …
disubstitued triazoles in a single atom‐economical step and offers advantages compared to …
Base-controlled Fe (Pc)-catalyzed aerobic oxidation of thiols for the synthesis of S–S and S–P (O) bonds
H Huang, J Ash, JY Kang - Organic & Biomolecular Chemistry, 2018 - pubs.rsc.org
Fe (Pc)-Catalyzed aerobic oxidation of thiols for the synthesis of disulfides has been
developed under mild reaction conditions. In addition, an aerobic oxidative cross …
developed under mild reaction conditions. In addition, an aerobic oxidative cross …
Application and Structural Analysis of Triazole‐Bridged Disulfide Mimetics in Cyclic Peptides
Ruthenium‐catalysed azide–alkyne cycloaddition (RuAAC) provides access to 1, 5‐
disubstituted 1, 2, 3‐triazole motifs in peptide engineering applications. However …
disubstituted 1, 2, 3‐triazole motifs in peptide engineering applications. However …