The holistic characterisation of the human internal chemical exposome using high-resolution
mass spectrometry (HRMS) would be a step forward to investigate the environmental …

Exercise intolerance is a major manifestation of post-acute sequelae of severe acute
respiratory syndrome coronavirus infection (PASC, or “long-COVID”). Exercise intolerance in …

Aging and chronic inflammation are independent risk factors for the development of
atherothrombosis and cardiovascular disease. We hypothesized that aging-associated …

Introduction: Recently, the classification of two 'novel'organs, the mesentere and interstitium,
was saluted as a scientific breakthrough and disseminated into mainstream media. The …

Chemotherapy remains the standard of care for most cancers worldwide, however
development of chemoresistance due to the presence of the drug-effluxing ATP binding …

Metabolomics has emerged in the past decade as a highly attractive and impactful
technique for phenotype-level profiling in diverse biological applications. Most recently, the …

Mitochondria are critical metabolic and signaling hubs, and dysregulated mitochondrial
homeostasis is implicated in many diseases. Degradation of damaged mitochondria by …

Red blood cell (RBC) metabolic reprogramming upon exposure to high altitude contributes
to physiological human adaptations to hypoxia, a multifaceted process critical to health and …

Circadian disruption aggravates age-related decline and mortality. However, it remains
unclear whether circadian enhancement can retard aging in mammals. We previously …

Our study details the stepwise evolution of gilteritinib resistance in FLT3-mutated acute
myeloid leukemia (AML). Early resistance is mediated by the bone marrow …