Glioblastoma (GBM) is the most deadly type of malignant brain tumor, despite extensive
molecular analyses of GBM cells. In recent years, the tumor microenvironment (TME) has …

The development of immunotherapies over the past decade has resulted in a paradigm shift
in the treatment of cancer. However, the majority of patients do not benefit from …

SLC7A11-mediated cystine uptake is critical for maintaining redox balance and cell survival.
Here we show that this comes at a significant cost for cancer cells with high levels of …

Cancer cell metabolism is heavily influenced by microenvironmental factors, including
nutrient availability. Therefore, knowledge of microenvironmental nutrient levels is essential …

Nucleotides are the foundational elements of life. Proliferative cells acquire nutrients for
energy production and the synthesis of macromolecules, including proteins, lipids, and …

Altered cellular metabolism is a hallmark of gliomas. Propelled by a set of recent
technological advances, new insights into the molecular mechanisms underlying glioma …

Nutrient stress in the tumor microenvironment requires cancer cells to adopt adaptive
metabolic programs for survival and proliferation. Therefore, knowledge of …

As the first rate-limiting enzyme in fatty acid oxidation (FAO), CPT1 plays a significant role in
metabolic adaptation in cancer pathogenesis. FAO provides an alternative energy supply for …

Cancer cell metabolism including aerobic glycolysis, amino acid and fatty acid metabolism,
has been extensively studied. Metabolic reprogramming is a major hallmark of cancer …

RNA modification, especially RNA methylation, is a critical posttranscriptional process
influencing cellular functions and disease progression, accounting for over 60% of all RNA …