[HTML][HTML] Advances in antibody phage display technology
Phage display technology can be used for the discovery of antibodies for research,
diagnostic, and therapeutic purposes. In this review, we present and discuss key parameters …
diagnostic, and therapeutic purposes. In this review, we present and discuss key parameters …
Bispecific antibodies: a mechanistic review of the pipeline
AF Labrijn, ML Janmaat, JM Reichert… - Nature reviews Drug …, 2019 - nature.com
The term bispecific antibody (bsAb) is used to describe a large family of molecules designed
to recognize two different epitopes or antigens. BsAbs come in many formats, ranging from …
to recognize two different epitopes or antigens. BsAbs come in many formats, ranging from …
The making of bispecific antibodies
U Brinkmann, RE Kontermann - MAbs, 2017 - Taylor & Francis
During the past two decades we have seen a phenomenal evolution of bispecific antibodies
for therapeutic applications. The 'zoo'of bispecific antibodies is populated by many different …
for therapeutic applications. The 'zoo'of bispecific antibodies is populated by many different …
IgE and IgG antibodies as regulators of mast cell and basophil functions in food allergy
C Kanagaratham, YS El Ansari, OL Lewis… - Frontiers in …, 2020 - frontiersin.org
Food allergy is a major health issue, affecting the lives of 8% of US children and their
families. There is an urgent need to identify the environmental and endogenous signals that …
families. There is an urgent need to identify the environmental and endogenous signals that …
[HTML][HTML] Alternative molecular formats and therapeutic applications for bispecific antibodies
C Spiess, Q Zhai, PJ Carter - Molecular immunology, 2015 - Elsevier
Bispecific antibodies are on the cusp of coming of age as therapeutics more than half a
century after they were first described. Two bispecific antibodies, catumaxomab (Removab® …
century after they were first described. Two bispecific antibodies, catumaxomab (Removab® …
Design and production of bispecific antibodies
With the current biotherapeutic market dominated by antibody molecules, bispecific
antibodies represent a key component of the next-generation of antibody therapy. Bispecific …
antibodies represent a key component of the next-generation of antibody therapy. Bispecific …
Considerations for the design of antibody-based therapeutics
Antibody-based proteins have become an important class of biologic therapeutics, due in
large part to the stability, specificity, and adaptability of the antibody framework. Indeed …
large part to the stability, specificity, and adaptability of the antibody framework. Indeed …
A bispecific antibody to factors IXa and X restores factor VIII hemostatic activity in a hemophilia A model
T Kitazawa, T Igawa, Z Sampei, A Muto, T Kojima… - Nature medicine, 2012 - nature.com
Hemophilia A is a bleeding disorder resulting from coagulation factor VIII (FVIII) deficiency.
Exogenously provided FVIII effectively reduces bleeding complications in patients with …
Exogenously provided FVIII effectively reduces bleeding complications in patients with …
Dual targeting strategies with bispecific antibodies
R Kontermann - MAbs, 2012 - Taylor & Francis
Monoclonal antibodies are widely used for the treatment of cancer, inflammatory and
infectious diseases and other disorders. Most of the marketed antibodies are monospecific …
infectious diseases and other disorders. Most of the marketed antibodies are monospecific …
Efficient generation of stable bispecific IgG1 by controlled Fab-arm exchange
AF Labrijn, JI Meesters… - Proceedings of the …, 2013 - National Acad Sciences
The promise of bispecific antibodies (bsAbs) to yield more effective therapeutics is well
recognized; however, the generation of bsAbs in a practical and cost-effective manner has …
recognized; however, the generation of bsAbs in a practical and cost-effective manner has …