Cilia mediate an astonishing diversity of processes. Recent advances provide unexpected
insights into the regulatory mechanisms of cilium formation, and reveal diverse regulatory …

The centriole is an ancient microtubule-based organelle with a conserved nine-fold
symmetry. Centrioles form the core of centrosomes, which organize the interphase …

The canonical mitotic cell cycle coordinates DNA replication, centriole duplication and
cytokinesis to generate two cells from one. Some cells, such as mammalian trophoblast …

Centriole biogenesis, as in most organelle assemblies, involves the sequential recruitment
of sub-structural elements that will support its function. To uncover this process, we …

The centrosome is the primary microtubule organizing center of the cells and templates the
formation of cilia, thereby operating at a nexus of critical cellular functions. Here, we use …

The primary cilium is an antenna-like, immotile organelle present on most types of
mammalian cells, which interprets extracellular signals that regulate growth and …

Cilia are plasma membrane protrusions that act as cellular propellers or antennae. To
perform these functions, cilia must maintain a composition distinct from those of the …

Centrosome amplification is a hallmark of cancer. However, despite significant progress in
recent years, we are still far from understanding how centrosome amplification affects …

Guanine nucleotide exchange factors (RhoGEFs) and GTPase-activating proteins
(RhoGAPs) coordinate the activation state of the Rho family of GTPases for binding to …

Centrosomes are microtubule-organizing centres of animal cells. They influence the
morphology of the microtubule cytoskeleton, function as the base for the primary cilium and …