Phosphodiesterases (PDEs), enzymes that degrade 3′, 5′-cyclic nucleotides, are being
pursued as therapeutic targets for several diseases, including those affecting the nervous …

Since its introduction almost 20 years ago, the tail suspension test has become one of the
most widely used models for assessing antidepressant-like activity in mice. The test is based …

Phosphodiesterases (PDEs) are enzymes involved in the homeostasis of both cAMP and
cGMP. They are members of a family of proteins that includes 11 subfamilies with different …

Cyclic nucleotide phosphodiesterases (PDEs), which are ubiquitously distributed in
mammalian tissues, play a major role in cell signaling by hydrolyzing cAMP and cGMP. Due …

The ability to modify mice genetically has been one of the major breakthroughs in modern
medical science affecting every discipline including psychiatry. It is hoped that the …

Major depressive disorder (MDD) is characterized by structural and neurochemical changes
in limbic structures, including the hippocampus, that regulate mood and cognitive functions …

Cyclic AMP (cAMP) is a key second messenger in all cells. It is compartmentalized within
cells and its levels are controlled, as a result of spatially discrete signaling cassettes …

To support the role of DISC1 in human psychiatric disorders, we identified and analyzed two
independently derived ENU-induced mutations in Exon 2 of mouse Disc1. Mice with …

The DISC locus is located at the breakpoint of a balanced t (1; 11) chromosomal
translocation in a large and unique Scottish family. This translocation segregates in a highly …

Major depression is a debilitating and recurrent disorder with a substantial lifetime risk and a
high social cost. Depressed patients generally display co-morbid symptoms, and depression …