It is difficult to overstate the cultural and biological impacts that the domestication of plants
and animals has had on our species. Fundamental questions regarding where, when, and …

Abstract The Dog Aging Project is a long-term longitudinal study of ageing in tens of
thousands of companion dogs. The domestic dog is among the most variable mammal …

Behavioral genetics in dogs has focused on modern breeds, which are isolated subgroups
with distinctive physical and, purportedly, behavioral characteristics. We interrogated breed …

Many aspects of the historical relationships between populations in a species are reflected
in genetic data. Inferring these relationships from genetic data, however, remains a …

The grey wolf (Canis lupus) was the first species to give rise to a domestic population, and
they remained widespread throughout the last Ice Age when many other large mammal …

Domestic dog breeds are characterized by an unrivaled diversity of morphologic traits and
breed-associated behaviors resulting from human selective pressures. To identify the …

To identify genetic changes underlying dog domestication and reconstruct their early
evolutionary history, we generated high-quality genome sequences from three gray wolves …

Comparing allele frequencies among populations that differ in environment has long been a
tool for detecting loci involved in local adaptation. However, such analyses are complicated …

Population bottlenecks, inbreeding, and artificial selection can all, in principle, influence
levels of deleterious genetic variation. However, the relative importance of each of these …

Studies using dogs provide an ideal solution to the gap in animal models for natural disease
and translational medicine. This is evidenced by approximately 400 inherited disorders …