Bringing structure to cell biology with cryo-electron tomography
Recent advances in cryo-electron microscopy have marked only the beginning of the
potential of this technique. To bring structure into cell biology, the modality of cryo-electron …
potential of this technique. To bring structure into cell biology, the modality of cryo-electron …
Structure and function of the nuclear pore complex
The nucleus, a genome-containing organelle eponymous of eukaryotes, is enclosed by a
double membrane continuous with the endoplasmic reticulum. The nuclear pore complex …
double membrane continuous with the endoplasmic reticulum. The nuclear pore complex …
Structure of cytoplasmic ring of nuclear pore complex by integrative cryo-EM and AlphaFold
INTRODUCTION The nuclear pore complex (NPC) is the molecular conduit in the nuclear
membrane of eukaryotic cells that regulates import and export of biomolecules between the …
membrane of eukaryotic cells that regulates import and export of biomolecules between the …
Lipid saturation controls nuclear envelope function
A Romanauska, A Köhler - Nature Cell Biology, 2023 - nature.com
The nuclear envelope (NE) is a spherical double membrane with elastic properties. How NE
shape and elasticity are regulated by lipid chemistry is unknown. Here we discover lipid acyl …
shape and elasticity are regulated by lipid chemistry is unknown. Here we discover lipid acyl …
Visualizing the disordered nuclear transport machinery in situ
The approximately 120 MDa mammalian nuclear pore complex (NPC) acts as a gatekeeper
for the transport between the nucleus and cytosol. The central channel of the NPC is filled …
for the transport between the nucleus and cytosol. The central channel of the NPC is filled …
Structure of the cytoplasmic ring of the Xenopus laevis nuclear pore complex
INTRODUCTION The nuclear pore complex (NPC) resides on the nuclear envelope (NE)
and mediates nucleocytoplasmic cargo transport. As one of the largest cellular machineries …
and mediates nucleocytoplasmic cargo transport. As one of the largest cellular machineries …
Protein import into peroxisomes occurs through a nuclear pore–like phase
Peroxisomes are ubiquitous organelles whose dysfunction causes fatal human diseases.
Most peroxisomal proteins are imported from the cytosol in a folded state by the soluble …
Most peroxisomal proteins are imported from the cytosol in a folded state by the soluble …
Docking a flexible basket onto the core of the nuclear pore complex
E Stankunas, A Köhler - Nature Cell Biology, 2024 - nature.com
The nuclear basket attaches to the nucleoplasmic side of the nuclear pore complex (NPC),
coupling transcription to mRNA quality control and export. The basket expands the …
coupling transcription to mRNA quality control and export. The basket expands the …
Implications of a multiscale structure of the yeast nuclear pore complex
CW Akey, I Echeverria, C Ouch, I Nudelman, Y Shi… - Molecular Cell, 2023 - cell.com
Nuclear pore complexes (NPCs) direct the nucleocytoplasmic transport of macromolecules.
Here, we provide a composite multiscale structure of the yeast NPC, based on improved 3D …
Here, we provide a composite multiscale structure of the yeast NPC, based on improved 3D …
Nuclear pore complexes mediate subtelomeric gene silencing by regulating PCNA levels on chromatin
The nuclear pore complex (NPC) physically interacts with chromatin and regulates gene
expression. The Saccharomyces cerevisiae inner ring nucleoporin Nup170 has been …
expression. The Saccharomyces cerevisiae inner ring nucleoporin Nup170 has been …