Cardiovascular disease is the leading contributor to years lost due to disability or premature
death among adults. Current efforts focus on risk prediction and risk factor mitigation ‚which …

• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

The systemic amyloidoses are a broad spectrum of diseases that result from misfolding of
proteins that aggregate into b-sheet amyloid fibrils. Over 35 amyloidogenic precursor …

Abstract Aim The “2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic
Disease” provides recommendations to guide clinicians in the diagnosis, genetic evaluation …

This contemporary, international, evidence-informed guidance aims to achieve the greatest
good for the greatest number of people with familial hypercholesterolaemia (FH) across …

Background: Each of the cardiomyopathies, classically categorized as hypertrophic
cardiomyopathy, dilated cardiomyopathy (DCM), and arrhythmogenic right ventricular …

In the past decade there has been a growing interest in understanding sex and gender
differences in myocarditis and dilated cardiomyopathy (DCM), and the purpose of this review …

Epilepsy, defined by the occurrence of two or more unprovoked seizures or one unprovoked
seizure with a propensity for others, affects 0.64% of the population and can lead to …

Background The risk of adverse cardiovascular events in patients with acute myocarditis
(AM) and desmosomal gene variants (DGV) remains unknown. Objectives The purpose of …

Background Diverse genetic backgrounds often lead to phenotypic heterogeneity in
cardiomyopathies (CMPs). Previous genotype-phenotype studies have primarily focused on …