For the past three decades, apolipoprotein E (APOE) has been known as the single greatest
genetic modulator of sporadic Alzheimer disease (AD) risk, influencing both the average age …

Lipid droplets (LDs) have recently garnered significant attention due to their pivotal roles in
life and diseases. Thus, seeking suitable tools to visualize the dynamics of LDs and reveal …

Alzheimer's disease (AD) is the leading cause of dementia in older adults. Although AD
progression is characterized by stereotyped accumulation of proteinopathies, the affected …

Identifying cell populations associated with risk variants is essential for uncovering cell-
specific mechanisms that drive disease development and progression. Integrating genome …

Alzheimer's disease (AD) is the most common neurodegenerative disorder, characterized
pathologically by extracellular deposition of β-amyloid (Aβ) into senile plaques and …

The accumulation of reactive oxygen species (ROS) is a common feature of tauopathies,
defined by Tau accumulations in neurons and glia. High ROS in neurons causes lipid …

Recent discoveries of rare variants of human APOE may shed light on novel therapeutic
strategies for Alzheimer's disease (AD). Here, we highlight the newly identified protective …

Abstract Alzheimer's disease (AD), the leading cause of dementia, is characterized by the
accumulation of amyloid plaques and neurofibrillary tangles in the brain. This condition …

While apolipoprotein E (APOE) is the strongest genetic modifier for late-onset Alzheimer's
disease (LOAD), the molecular mechanisms underlying isoform-dependent risk and the …

Microglia, the resident immune cells of the central nervous system, emerge in the brain
during early embryonic development and persist throughout life. They play essential roles in …