Multi-drug resistance (MDR) in cancer cells, either intrinsic or acquired through various
mechanisms, significantly hinders the therapeutic efficacy of drugs. Typically, the reduced …

The development of supramolecular chemistry dates back to 1987 when Lehn, Cram, and
Pedersen won the Nobel Prize on account of their leading discoveries in the host–guest …

Conspectus Efficient assembly in host–guest interactions is crucial to supramolecular
nanotechnology. Cyclodextrins (CDs), which possess a hydrophilic exterior surface and …

In the last 30 years we have assisted to a massive advance of nanomaterials in material
science. Nanomaterials and structures, in addition to their small size, have properties that …

Organic–inorganic hybrid materials aiming to combine the individual advantages of organic
and inorganic components while overcoming their intrinsic drawbacks have shown great …

Cancer is a highly complex disease to understand, because it entails multiple cellular
physiological systems. The most common cancer treatments are restricted to chemotherapy …

Multidrug resistance is the most widely exploited phenomenon by which cancer eludes
chemotherapy. Broad variety of factors, ranging from the cellular ones, such as over …

To achieve superior therapeutic efficacy, the combination chemotherapy using two or more
anticancer drugs in clinical practice has been generally accepted as a feasible strategy. On …

Conspectus Certain genetic mutations lead to the development of cancer through
unchecked cell growth and division. Cancer is typically treated through surgical resection …

There are two main mechanisms by which cells become multidrug resistant (MDR): by
increasing drug efflux pumps on the cell membrane and by increasing anti-apoptotic …