Phage diversity, genomics and phylogeny

MB Dion, F Oechslin, S Moineau - Nature Reviews Microbiology, 2020 - nature.com
Recent advances in viral metagenomics have enabled the rapid discovery of an
unprecedented catalogue of phages in numerous environments, from the human gut to the …

Embracing the enemy: the diversification of microbial gene repertoires by phage-mediated horizontal gene transfer

M Touchon, JAM De Sousa, EPC Rocha - Current opinion in microbiology, 2017 - Elsevier
Highlights•Phages drive horizontal gene transfer between prokaryotes.•Lysogenic
conversion provides novel adaptive traits, at the cost of eventual lysis.•Prophages account …

Phage-plasmids promote recombination and emergence of phages and plasmids

E Pfeifer, EPC Rocha - Nature Communications, 2024 - nature.com
Phages and plasmids are regarded as distinct types of mobile genetic elements that drive
bacterial evolution by horizontal gene transfer. However, the distinction between both types …

Expansion of bacteriophages is linked to aggravated intestinal inflammation and colitis

L Gogokhia, K Buhrke, R Bell, B Hoffman, DG Brown… - Cell host & …, 2019 - cell.com
Bacteriophages are the most abundant members of the microbiota and have the potential to
shape gut bacterial communities. Changes to bacteriophage composition are associated …

Transfer of antibiotic resistance in Staphylococcus aureus

J Haaber, JR Penadés, H Ingmer - Trends in microbiology, 2017 - cell.com
Staphylococcus aureus is a serious human pathogen with remarkable adaptive powers.
Antibiotic-resistant clones rapidly emerge mainly by acquisition of antibiotic-resistance …

Resolving the structure of phage–bacteria interactions in the context of natural diversity

KM Kauffman, WK Chang, JM Brown… - Nature …, 2022 - nature.com
Microbial communities are shaped by viral predators. Yet, resolving which viruses (phages)
and bacteria are interacting is a major challenge in the context of natural levels of microbial …

Pervasive domestication of defective prophages by bacteria

LM Bobay, M Touchon, EPC Rocha - … of the National Academy of Sciences, 2014 - pnas.org
Integrated phages (prophages) are major contributors to the diversity of bacterial gene
repertoires. Domestication of their components is thought to have endowed bacteria with …

The disparate effects of bacteriophages on antibiotic-resistant bacteria

C Torres-Barceló - Emerging microbes & infections, 2018 - Taylor & Francis
Faced with the crisis of multidrug-resistant bacteria, bacteriophages, viruses that infect and
replicate within bacteria, have been reported to have both beneficial and detrimental effects …

Lysogeny in nature: mechanisms, impact and ecology of temperate phages

C Howard-Varona, KR Hargreaves, ST Abedon… - The ISME …, 2017 - academic.oup.com
Viruses that infect bacteria (phages) can influence bacterial community dynamics, bacterial
genome evolution and ecosystem biogeochemistry. These influences differ depending on …

Ecological and evolutionary benefits of temperate phage: what does or doesn't kill you makes you stronger

E Harrison, MA Brockhurst - BioEssays, 2017 - Wiley Online Library
Infection by a temperate phage can lead to death of the bacterial cell, but sometimes these
phages integrate into the bacterial chromosome, offering the potential for a more long …