Atherosclerosis imposes a heavy burden on cardiovascular health due to its indispensable
role in the pathogenesis of cardiovascular disease (CVD) such as coronary artery disease …

The nucleophosmin (NPM1) gene encodes for a multifunctional chaperone protein that is
localized in the nucleolus but continuously shuttles between the nucleus and cytoplasm …

Acute Myeloid Leukemia - StatPearls - NCBI Bookshelf US flag An official website of the United
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Monotherapy with Menin inhibitor (MI), eg, SNDX-5613, induces clinical remissions in
patients with relapsed/refractory AML harboring MLL1-r or mtNPM1, but most patients either …

Simple Summary The nucleophosmin 1 (NPM1) gene is mutated in approximately one-third
of newly diagnosed acute myeloid leukemia (AML) cases. NPM1mutated AML (NPM1 mut …

The updated WHO 5th edition and ICC 2022 classification systems for AML aim to refine our
diagnostic criteria and definitions of AML with deeper incorporation of cytogenetic and …

The most common kind of acute leukemia in adults is acute myeloid leukemia (AML), which
is often treated with induction chemotherapy regimens followed by consolidation or …

Simple Summary Next–Generation Sequencing (NGS) has provided a deeper genetic
understanding of acute myeloid leukemia (AML) that has been recently incorporated into …

Mutations in NPM1, also known as nucleophosmin-1, B23, NO38, or numatrin, are seen in
approximately one-third of patients with acute myeloid leukaemia (AML). A plethora of …

The direct targeting of chromatin-associated proteins is increasingly recognized as a
potential therapeutic strategy for the treatment of cancer. In this review, we discuss a …