T-type Ca2+ channels were originally called low-voltage-activated (LVA) channels because
they can be activated by small depolarizations of the plasma membrane. In many neurons …

The heart automaticity is a fundamental physiological function in higher organisms. The
spontaneous activity is initiated by specialized populations of cardiac cells generating …

The generation of the mammalian heartbeat is a complex and vital function requiring
multiple and coordinated ionic channel activities. The functional role of low-voltage activated …

Results Micromolar concentrations of anandamide inhibited the three human cloned T‐
channels α 1G (Ca V 3.1), α 1H (Ca V 3.2) and α 1I (Ca V 3.3) expressed in HEK 293 cells …

The regulation of presynaptic, voltage-gated calcium channels by activation of heptahelical
G protein-coupled receptors exerts a crucial influence on presynaptic calcium entry and …

Voltage-gated calcium channels represent a heterogenous family of calcium-selective
channels that can be distinguished by their molecular, electrophysiological, and …

In several types of neurons, firing is an intrinsic property produced by specific classes of ion
channels. Low‐voltage‐activated T‐type calcium channels (T‐channels), which activate with …

Experimental nerve injury results in exaggerated responses to tactile and thermal stimuli that
resemble some aspects of human neuropathic pain. Neuronal hyperexcitability and …

Two different Ca2+ channels exist in cardiac myocytes. While the L-type Ca2+ channel is
ubiquitous and the main source of Ca2+ for excitation–contraction coupling and pacemaker …

The idiopathic generalized epilepsies encompass a class of epileptic seizure types that
exhibit a polygenic and heritable etiology. Advances in molecular biology and genetics have …