Biological plausibility linking sleep apnoea and metabolic dysfunction

A Gileles-Hillel, L Kheirandish-Gozal… - Nature Reviews …, 2016 - nature.com
Obstructive sleep apnoea (OSA) is a very common disorder that affects 10–25% of the
general population. In the past two decades, OSA has emerged as a cardiometabolic risk …

The bidirectional relationship between obstructive sleep apnea and metabolic disease

SN Framnes, DM Arble - Frontiers in Endocrinology, 2018 - frontiersin.org
Obstructive sleep apnea (OSA) is a common sleep disorder, effecting 17% of the total
population and 40–70% of the obese population (,). Multiple studies have identified OSA as …

Obstructive sleep apnea and cardiovascular disease: a perspective and future directions

AI Pack, T Gislason - Progress in cardiovascular diseases, 2009 - Elsevier
Data from animal and human studies provide a biological plausibility to the notion that
obstructive sleep apnea activates pathways that lead to insulin resistance, atherosclerosis …

Obstructive sleep apnea and systemic hypertension: gut dysbiosis as the mediator?

S Mashaqi, D Gozal - Journal of Clinical Sleep Medicine, 2019 - jcsm.aasm.org
Introduction: Obstructive sleep apnea (OSA) and systemic hypertension (SH) are common
and interrelated diseases. It is estimated that approximately 75% of treatment-resistant …

Cardiovascular consequences of sleep-disordered breathing: contribution of animal models to understanding of the human disease

M Dematteis, D Godin-Ribuot, C Arnaud, C Ribuot… - ILAR …, 2009 - academic.oup.com
Sleep-disordered breathing, and particularly the highly prevalent obstructive sleep apnea
syndrome, is a multicomponent disorder combining intermittent hypoxia (IH), sleep …

The impact of obstructive sleep apnea and PAP therapy on all-cause and cardiovascular mortality based on age and gender–a literature review

S Mashaqi, D Gozal - Respiratory investigation, 2020 - Elsevier
Background Obstructive sleep apnea (OSA) is a common sleep disorder which negatively
impacts different body systems, especially the cardiovascular system. The correlation …

Respiratory modulation of premotor cardiac vagal neurons in the brainstem

O Dergacheva, KJ Griffioen, RA Neff… - Respiratory physiology & …, 2010 - Elsevier
The respiratory and cardiovascular systems are highly intertwined, both anatomically and
physiologically. Respiratory and cardiovascular neurons are often co-localized in the same …

Sympathetic and catecholaminergic alterations in sleep apnea with particular emphasis on children

F Hakim, D Gozal, L Kheirandish-Gozal - Frontiers in neurology, 2012 - frontiersin.org
Sleep is involved in the regulation of major organ functions in the human body, and
disruption of sleep potentially can elicit organ dysfunction. Obstructive sleep apnea (OSA) is …

Topographical map** of catecholaminergic axon innervation in the flat-mounts of the mouse atria: a quantitative analysis

Y Zhang, A Bizanti, SW Harden, J Chen… - Scientific reports, 2023 - nature.com
The sympathetic nervous system is crucial for controlling multiple cardiac functions.
However, a comprehensive, detailed neuroanatomical map of the sympathetic innervation of …

Neuromodulation of limb proprioceptive afferents decreases apnea of prematurity and accompanying intermittent hypoxia and bradycardia

K Kesavan, P Frank, DM Cordero, P Benharash… - PloS one, 2016 - journals.plos.org
Background Apnea of Prematurity (AOP) is common, affecting the majority of infants born at<
34 weeks gestational age. Apnea and periodic breathing are accompanied by intermittent …