Ape origins of human malaria

PM Sharp, LJ Plenderleith… - Annual review of …, 2020 - annualreviews.org
African apes harbor at least twelve Plasmodium species, some of which have been a source
of human infection. It is now well established that Plasmodium falciparum emerged following …

Plasmodium vivax Biology: Insights Provided by Genomics, Transcriptomics and Proteomics

C Bourgard, L Albrecht, ACAV Kayano… - Frontiers in cellular …, 2018 - frontiersin.org
During the last decade, the vast omics field has revolutionized biological research,
especially the genomics, transcriptomics and proteomics branches, as technological tools …

Malaria protection due to sickle haemoglobin depends on parasite genotype

G Band, EM Leffler, M Jallow, F Sisay-Joof, CM Ndila… - Nature, 2022 - nature.com
Host genetic factors can confer resistance against malaria, raising the question of whether
this has led to evolutionary adaptation of parasite populations. Here we searched for …

Extreme mutation bias and high AT content in Plasmodium falciparum

WL Hamilton, A Claessens, TD Otto… - Nucleic acids …, 2017 - academic.oup.com
For reasons that remain unknown, the Plasmodium falciparum genome has an exceptionally
high AT content compared to other Plasmodium species and eukaryotes in general-nearly …

THE REAL McCOIL: A method for the concurrent estimation of the complexity of infection and SNP allele frequency for malaria parasites

HH Chang, CJ Worby, A Yeka… - PLoS computational …, 2017 - journals.plos.org
As many malaria-endemic countries move towards elimination of Plasmodium falciparum,
the most virulent human malaria parasite, effective tools for monitoring malaria epidemiology …

Map** imported malaria in Bangladesh using parasite genetic and human mobility data

HH Chang, A Wesolowski, I Sinha, CG Jacob… - Elife, 2019 - elifesciences.org
For countries aiming for malaria elimination, travel of infected individuals between endemic
areas undermines local interventions. Quantifying parasite importation has therefore …

Map** malaria by combining parasite genomic and epidemiologic data

A Wesolowski, AR Taylor, HH Chang, R Verity… - BMC medicine, 2018 - Springer
Background Recent global progress in scaling up malaria control interventions has revived
the goal of complete elimination in many countries. Decreasing transmission intensity …

Genome-Wide Analysis of Selection on the Malaria Parasite Plasmodium falciparum in West African Populations of Differing Infection Endemicity

VA Mobegi, CW Duffy… - Molecular Biology …, 2014 - academic.oup.com
Locally varying selection on pathogens may be due to differences in drug pressure, host
immunity, transmission opportunities between hosts, or the intensity of between-genotype …

Population parameters underlying an ongoing soft sweep in Southeast Asian malaria parasites

TJC Anderson, S Nair, M McDew-White… - Molecular biology …, 2017 - academic.oup.com
Multiple kelch13 alleles conferring artemisinin resistance (ART-R) are currently spreading
through Southeast Asian malaria parasite populations, providing a unique opportunity to …

Evolutionary history of human Plasmodium vivax revealed by genome-wide analyses of related ape parasites

DE Loy, LJ Plenderleith… - Proceedings of the …, 2018 - National Acad Sciences
Wild-living African apes are endemically infected with parasites that are closely related to
human Plasmodium vivax, a leading cause of malaria outside Africa. This finding suggests …