Critical role of microRNA-21 in the pathogenesis of liver diseases
MicroRNAs are small non-coding RNAs that range in length from 18 to 24 nucleotides. As
one of the most extensively studied microRNAs, microRNA-21 (miR-21) is highly expressed …
one of the most extensively studied microRNAs, microRNA-21 (miR-21) is highly expressed …
Molecular and tissue alterations of collagens in fibrosis
S Ricard-Blum, G Baffet, N Théret - Matrix Biology, 2018 - Elsevier
The collagen network is altered in fibrotic diseases associated with extracellular matrix
(ECM) biosynthesis and remodeling. This mini-review focuses on the quantitative and …
(ECM) biosynthesis and remodeling. This mini-review focuses on the quantitative and …
Interaction between alcohol consumption and metabolic syndrome in predicting severe liver disease in the general population
F Åberg, J Helenius‐Hietala, P Puukka, M Färkkilä… - Hepatology, 2018 - journals.lww.com
Several staging systems for hepatocellular carcinoma (HCC) have been developed. The
Barcelona Clinic Liver Cancer staging system is considered the best in predicting survival …
Barcelona Clinic Liver Cancer staging system is considered the best in predicting survival …
miR‐21‐5p promotes NASH‐related hepatocarcinogenesis
Abstract Background and Aims The mechanisms governing the progression of non‐
alcoholic fatty liver disease (NAFLD) towards steatohepatitis (NASH) and hepatocellular …
alcoholic fatty liver disease (NAFLD) towards steatohepatitis (NASH) and hepatocellular …
microRNA-21, via the HIF-1α/VEGF signaling pathway, is involved in arsenite-induced hepatic fibrosis through aberrant cross-talk of hepatocytes and hepatic stellate …
J Sun, L Shi, T **ao, J Xue, J Li, P Wang, L Wu, X Dai… - Chemosphere, 2021 - Elsevier
Long-term exposure to arsenic, a widely distributed environmental toxicant, may result in
damage to various organs, including the liver. Mice exposed chronically to arsenite …
damage to various organs, including the liver. Mice exposed chronically to arsenite …
miRNA-21 ablation protects against liver injury and necroptosis in cholestasis
Abstract Inhibition of microRNA-21 (miR-21) prevents necroptosis in the mouse pancreas.
Necroptosis contributes to hepatic necro-inflammation in the common bile duct ligation …
Necroptosis contributes to hepatic necro-inflammation in the common bile duct ligation …
Secretin alleviates biliary and liver injury during late-stage primary biliary cholangitis via restoration of secretory processes
Background & Aims Primary biliary cholangitis (PBC) is characterised by ductopenia,
ductular reaction, impairment of anion exchanger 2 (AE2) and the 'bicarbonate umbrella' …
ductular reaction, impairment of anion exchanger 2 (AE2) and the 'bicarbonate umbrella' …
A large‐scale multicenter study validates aldo‐keto reductase family 1 member B10 as a prevalent serum marker for detection of hepatocellular carcinoma
X Ye, C Li, X Zu, M Lin, Q Liu, J Liu, G Xu, Z Chen… - Hepatology, 2019 - journals.lww.com
Cholangiopathies are diseases that affect cholangiocytes, the cells lining the biliary tract.
Liver stem cells (LSCs) are able to differentiate into all cells of the liver and possibly …
Liver stem cells (LSCs) are able to differentiate into all cells of the liver and possibly …
[PDF][PDF] MicroRNA‐21 and Dicer are dispensable for hepatic stellate cell activation and the development of liver fibrosis
Fibrosis and cancer represent two major complications of chronic liver disease. MicroRNAs
have been implicated in the development of fibrosis and cancer, thus constituting potential …
have been implicated in the development of fibrosis and cancer, thus constituting potential …
MicroRNA-21 deficiency suppresses prostate cancer progression through downregulation of the IRS1-SREBP-1 signaling pathway
Sterol regulatory element-binding protein 1 (SREBP-1), a master transcription factor in
lipogenesis and lipid metabolism, is critical for disease progression and associated with …
lipogenesis and lipid metabolism, is critical for disease progression and associated with …