Ilastik: interactive machine learning for (bio) image analysis

S Berg, D Kutra, T Kroeger, CN Straehle, BX Kausler… - Nature …, 2019 - nature.com
We present ilastik, an easy-to-use interactive tool that brings machine-learning-based (bio)
image analysis to end users without substantial computational expertise. It contains pre …

Neuronal cell-type classification: challenges, opportunities and the path forward

H Zeng, JR Sanes - Nature Reviews Neuroscience, 2017 - nature.com
Neurons have diverse molecular, morphological, connectional and functional properties. We
believe that the only realistic way to manage this complexity—and thereby pave the way for …

Integrative imaging reveals SARS-CoV-2-induced resha** of subcellular morphologies

M Cortese, JY Lee, B Cerikan, CJ Neufeldt… - Cell host & …, 2020 - cell.com
Pathogenesis induced by SARS-CoV-2 is thought to result from both an inflammation-
dominated cytokine response and virus-induced cell perturbation causing cell death. Here …

A complete electron microscopy volume of the brain of adult Drosophila melanogaster

Z Zheng, JS Lauritzen, E Perlman, CG Robinson… - Cell, 2018 - cell.com
Drosophila melanogaster has a rich repertoire of innate and learned behaviors. Its 100,000-
neuron brain is a large but tractable target for comprehensive neural circuit map**. Only …

Integration of spatial and single-cell transcriptomic data elucidates mouse organogenesis

T Lohoff, S Ghazanfar, A Missarova, N Koulena… - Nature …, 2022 - nature.com
Molecular profiling of single cells has advanced our knowledge of the molecular basis of
development. However, current approaches mostly rely on dissociating cells from tissues …

Content-aware image restoration: pushing the limits of fluorescence microscopy

M Weigert, U Schmidt, T Boothe, A Müller, A Dibrov… - Nature …, 2018 - nature.com
Fluorescence microscopy is a key driver of discoveries in the life sciences, with observable
phenomena being limited by the optics of the microscope, the chemistry of the fluorophores …

Learning steerable filters for rotation equivariant cnns

M Weiler, FA Hamprecht… - Proceedings of the IEEE …, 2018 - openaccess.thecvf.com
In many machine learning tasks it is desirable that a model's prediction transforms in an
equivariant way under transformations of its input. Convolutional neural networks (CNNs) …

Accurate and versatile 3D segmentation of plant tissues at cellular resolution

A Wolny, L Cerrone, A Vijayan, R Tofanelli, AV Barro… - Elife, 2020 - elifesciences.org
Quantitative analysis of plant and animal morphogenesis requires accurate segmentation of
individual cells in volumetric images of growing organs. In the last years, deep learning has …

[HTML][HTML] Multimodal analysis of cell types in a hypothalamic node controlling social behavior

DW Kim, Z Yao, LT Graybuck, TK Kim, TN Nguyen… - Cell, 2019 - cell.com
The ventrolateral subdivision of the ventromedial hypothalamus (VMHvl) contains∼ 4,000
neurons that project to multiple targets and control innate social behaviors including …

High-precision automated reconstruction of neurons with flood-filling networks

M Januszewski, J Kornfeld, PH Li, A Pope, T Blakely… - Nature …, 2018 - nature.com
Reconstruction of neural circuits from volume electron microscopy data requires the tracing
of cells in their entirety, including all their neurites. Automated approaches have been …