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Endoplasmic reticulum stress—a key guardian in cancer
W Zhang, Y Shi, L Oyang, S Cui, S Li, J Li, L Liu… - Cell Death …, 2024 - nature.com
Endoplasmic reticulum stress (ERS) is a cellular stress response characterized by excessive
contraction of the endoplasmic reticulum (ER). It is a pathological hallmark of many …
contraction of the endoplasmic reticulum (ER). It is a pathological hallmark of many …
The ER stress/UPR axis in chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis
Cellular protein homeostasis in the lungs is constantly disrupted by recurrent exposure to
various external and internal stressors, which may cause considerable protein secretion …
various external and internal stressors, which may cause considerable protein secretion …
Understanding molecular mechanisms of phenotype switching and crosstalk with TME to reveal new vulnerabilities of melanoma
A Najem, L Soumoy, M Sabbah, M Krayem, A Awada… - Cells, 2022 - mdpi.com
Melanoma cells are notorious for their high plasticity and ability to switch back and forth
between various melanoma cell states, enabling the adaptation to sub-optimal conditions …
between various melanoma cell states, enabling the adaptation to sub-optimal conditions …
Regulators at Every Step—How microRNAs Drive Tumor Cell Invasiveness and Metastasis
Simple Summary Tumor cell invasiveness and metastasis are key processes in cancer
progression and are composed of many steps. All of them are regulated by multiple …
progression and are composed of many steps. All of them are regulated by multiple …
The road of solid tumor survival: From drug-induced endoplasmic reticulum stress to drug resistance
S Cao, J Tang, Y Huang, G Li, Z Li, W Cai… - Frontiers in Molecular …, 2021 - frontiersin.org
Endoplasmic reticulum stress (ERS), which refers to a series of adaptive responses to the
disruption of endoplasmic reticulum (ER) homeostasis, occurs when cells are treated by …
disruption of endoplasmic reticulum (ER) homeostasis, occurs when cells are treated by …
Advances in Understanding Drug Resistance Mechanisms and Innovative Clinical Treatments for Melanoma
X He, H Deng, W Liu, L Hu, X Tan - Current Treatment Options in …, 2024 - Springer
Melanoma, a highly invasive skin cancer resulting from melanocyte malignant
transformation, is the third most common skin malignancy. Despite accounting for only 4% to …
transformation, is the third most common skin malignancy. Despite accounting for only 4% to …
[HTML][HTML] BRAF/EZH2 signaling represses miR-129-5p inhibition of SOX4 thereby modulating BRAFi resistance in melanoma
K Gebhardt, B Edemir, E Gross, L Nemetschke… - Cancers, 2021 - mdpi.com
Simple Summary Approximately 60% of all melanomas are associated with a constitutive
activating BRAF mutation. Inhibition of BRAF downstream signaling by targeted therapies …
activating BRAF mutation. Inhibition of BRAF downstream signaling by targeted therapies …
miR-96-5p, miR-134-5p, miR-181b-5p and miR-200b-3p heterogenous expression in sites of prostate cancer versus benign prostate hyperplasia—Archival samples …
MicroRNAs are involved in various pathologies including cancer. The aim of the study was
to assess the level of expression of miR-96-5p,-134-5p,-181b-5p,-200b-3p in FFPE samples …
to assess the level of expression of miR-96-5p,-134-5p,-181b-5p,-200b-3p in FFPE samples …
[HTML][HTML] Circular RNA ZNF609 drives tumor progression by regulating the miR-138-5p/SIRT7 axis in melanoma
Q Liu, W Cui, C Yang, LP Du - Aging (Albany NY), 2021 - pmc.ncbi.nlm.nih.gov
Melanoma serves as a prevailing and lethal skin malignancy with high mortality and a
growing number of patients globally. Circular RNAs (circRNAs), as a type of emerging …
growing number of patients globally. Circular RNAs (circRNAs), as a type of emerging …
Decreased expression of miR-23b is associated with poor survival of endometrial cancer patients
Endometrial cancer (EC) is one of the most common types of cancer of the female
reproductive system. EC is classified into two types (EC1 and EC2). MiRNAs are single …
reproductive system. EC is classified into two types (EC1 and EC2). MiRNAs are single …