Endoplasmic reticulum stress—a key guardian in cancer

W Zhang, Y Shi, L Oyang, S Cui, S Li, J Li, L Liu… - Cell Death …, 2024 - nature.com
Endoplasmic reticulum stress (ERS) is a cellular stress response characterized by excessive
contraction of the endoplasmic reticulum (ER). It is a pathological hallmark of many …

The ER stress/UPR axis in chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis

M Aghaei, S Dastghaib, S Aftabi, MR Aghanoori… - Life, 2020 - mdpi.com
Cellular protein homeostasis in the lungs is constantly disrupted by recurrent exposure to
various external and internal stressors, which may cause considerable protein secretion …

Understanding molecular mechanisms of phenotype switching and crosstalk with TME to reveal new vulnerabilities of melanoma

A Najem, L Soumoy, M Sabbah, M Krayem, A Awada… - Cells, 2022 - mdpi.com
Melanoma cells are notorious for their high plasticity and ability to switch back and forth
between various melanoma cell states, enabling the adaptation to sub-optimal conditions …

Regulators at Every Step—How microRNAs Drive Tumor Cell Invasiveness and Metastasis

TM Grzywa, K Klicka, PK Włodarski - Cancers, 2020 - mdpi.com
Simple Summary Tumor cell invasiveness and metastasis are key processes in cancer
progression and are composed of many steps. All of them are regulated by multiple …

The road of solid tumor survival: From drug-induced endoplasmic reticulum stress to drug resistance

S Cao, J Tang, Y Huang, G Li, Z Li, W Cai… - Frontiers in Molecular …, 2021 - frontiersin.org
Endoplasmic reticulum stress (ERS), which refers to a series of adaptive responses to the
disruption of endoplasmic reticulum (ER) homeostasis, occurs when cells are treated by …

Advances in Understanding Drug Resistance Mechanisms and Innovative Clinical Treatments for Melanoma

X He, H Deng, W Liu, L Hu, X Tan - Current Treatment Options in …, 2024 - Springer
Melanoma, a highly invasive skin cancer resulting from melanocyte malignant
transformation, is the third most common skin malignancy. Despite accounting for only 4% to …

[HTML][HTML] BRAF/EZH2 signaling represses miR-129-5p inhibition of SOX4 thereby modulating BRAFi resistance in melanoma

K Gebhardt, B Edemir, E Gross, L Nemetschke… - Cancers, 2021 - mdpi.com
Simple Summary Approximately 60% of all melanomas are associated with a constitutive
activating BRAF mutation. Inhibition of BRAF downstream signaling by targeted therapies …

miR-96-5p, miR-134-5p, miR-181b-5p and miR-200b-3p heterogenous expression in sites of prostate cancer versus benign prostate hyperplasia—Archival samples …

K Pełka, K Klicka, TM Grzywa, A Gondek… - Histochemistry and Cell …, 2021 - Springer
MicroRNAs are involved in various pathologies including cancer. The aim of the study was
to assess the level of expression of miR-96-5p,-134-5p,-181b-5p,-200b-3p in FFPE samples …

[HTML][HTML] Circular RNA ZNF609 drives tumor progression by regulating the miR-138-5p/SIRT7 axis in melanoma

Q Liu, W Cui, C Yang, LP Du - Aging (Albany NY), 2021 - pmc.ncbi.nlm.nih.gov
Melanoma serves as a prevailing and lethal skin malignancy with high mortality and a
growing number of patients globally. Circular RNAs (circRNAs), as a type of emerging …

Decreased expression of miR-23b is associated with poor survival of endometrial cancer patients

K Klicka, TM Grzywa, A Klinke, A Mielniczuk… - Scientific Reports, 2022 - nature.com
Endometrial cancer (EC) is one of the most common types of cancer of the female
reproductive system. EC is classified into two types (EC1 and EC2). MiRNAs are single …