Abstract Lynch, MA. Long-Term Potentiation and Memory. Physiol Rev 84: 87–136, 2004;
10.1152/physrev. 00014.2003.—One of the most significant challenges in neuroscience is to …

▪ Abstract Activity-dependent changes in synaptic function are believed to underlie the
formation of memories. Two prominent examples are long-term potentiation (LTP) and long …

The highly disagreeable sensation of pain results from an extraordinarily complex and
interactive series of mechanisms integrated at all levels of the neuroaxis, from the periphery …

Spanning functions from the simplest reflex arc to complex cognitive processes, neural
circuits have diverse functional roles. In the cerebral cortex, functional domains such as …

The establishment of neural circuitry requires vast numbers of synapses to be generated
during a specific window of brain development, but it is not known why the develo** …

Newly generated excitatory synapses in the mammalian cortex lack sufficient AMPA-type
glutamate receptors to mediate neurotransmission, resulting in functionally silent synapses …

Cl− channels reside both in the plasma membrane and in intracellular organelles. Their
functions range from ion homeostasis to cell volume regulation, transepithelial transport, and …

Excitatory synapses in the CNS release glutamate, which acts primarily on two types of
ionotropic receptors: AMPA receptors and NMDA receptors. AMPA receptors mediate the …

AMPA-type glutamate receptors (AMPA-Rs) mediate a majority of excitatory synaptic
transmission in the brain. In hippocampus, most AMPA-Rs are hetero-oligomers composed …

Determination of the molecular architecture of synapses requires nanoscopic image
resolution and specific molecular recognition, a task that has so far defied many …