In the early 2000s, Tawfik presented his 'New View'on enzyme evolution, highlighting the
role of conformational plasticity in expanding the functional diversity of limited repertoires of …

Global environmental issues and sustainable development call for new technologies for fine
chemical synthesis and waste valorization. Biocatalysis has attracted great attention as the …

Enzymes, with their specific catalyzed reactions, are necessary for all aspects of life,
enabling diverse biological processes and adaptations. Predicting enzyme functions is …

Understanding enzyme mechanisms is essential for unraveling the complex molecular
machinery of life. In this review, we survey the field of computational enzymology …

As genomic databases expand and artificial intelligence tools advance, there is a growing
demand for efficient characterization of large numbers of proteins. To this end, here we …

Biocatalysis has emerged as a green approach for efficient and sustainable production in
various industries. In recent decades, numerous advancements in computational and …

Biocatalysis is a thriving field of research because of the vast, environmentally friendly
impact that enzymes have on industry and biotechnology. However, in most production …

Enzyme design is a critical area in biotechnology, with applications ranging from drug
development to synthetic biology. Traditional methods for enzyme function prediction or …

Lipolytic enzymes include triacylglycerol lipases (EC 3.1. 1.3) and esterases (EC 3.1. 1.1)
that catalyze the cleavage and formation of ester bonds. They are potential industrial …

The rapid growth of sequence databases over the past two decades means that protein
engineers faced with optimizing a protein for any given task will often have immediate …