[HTML][HTML] A practical guide to small angle X-ray scattering (SAXS) of flexible and intrinsically disordered proteins
AG Kikhney, DI Svergun - FEBS letters, 2015 - Elsevier
Small-angle X-ray scattering (SAXS) is a biophysical method to study the overall shape and
structural transitions of biological macromolecules in solution. SAXS provides low resolution …
structural transitions of biological macromolecules in solution. SAXS provides low resolution …
Amyloid β protein and Alzheimer's disease: When computer simulations complement experimental studies
Alzheimer's disease (AD) challenges our society with an annual estimated cost of $1.08
trillion in the United States alone by 2050. 1 AD is a progressive irreversible neurological …
trillion in the United States alone by 2050. 1 AD is a progressive irreversible neurological …
Develo** a molecular dynamics force field for both folded and disordered protein states
Molecular dynamics (MD) simulation is a valuable tool for characterizing the structural
dynamics of folded proteins and should be similarly applicable to disordered proteins and …
dynamics of folded proteins and should be similarly applicable to disordered proteins and …
Conformational ensembles of an intrinsically disordered protein consistent with NMR, SAXS, and single-molecule FRET
GNW Gomes, M Krzeminski, A Namini… - Journal of the …, 2020 - ACS Publications
Intrinsically disordered proteins (IDPs) have fluctuating heterogeneous conformations, which
makes their structural characterization challenging. Although challenging, characterization …
makes their structural characterization challenging. Although challenging, characterization …
Exploring free-energy landscapes of intrinsically disordered proteins at atomic resolution using NMR spectroscopy
The last 15 years have seen a paradigm shift in our understanding of protein biochemistry,
with the realization that an unexpectedly high fraction of the human genome codes for …
with the realization that an unexpectedly high fraction of the human genome codes for …
How random are intrinsically disordered proteins? A small angle scattering perspective
V Receveur-Bréchot, D Durand - Current Protein and Peptide …, 2012 - ingentaconnect.com
While the crucial role of intrinsically disordered proteins (IDPs) in the cell cycle is now
recognized, deciphering their molecular mode of action at the structural level still remains …
recognized, deciphering their molecular mode of action at the structural level still remains …
Sequence determinants of compaction in intrinsically disordered proteins
Intrinsically disordered proteins (IDPs), which lack folded structure and are disordered under
nondenaturing conditions, have been shown to perform important functions in a large …
nondenaturing conditions, have been shown to perform important functions in a large …
Visualizing transient dark states by NMR spectroscopy
Myriad biological processes proceed through states that defy characterization by
conventional atomic-resolution structural biological methods. The invisibility of these …
conventional atomic-resolution structural biological methods. The invisibility of these …
Structural analysis of intrinsically disordered proteins by small-angle X-ray scattering
P Bernado, DI Svergun - Molecular biosystems, 2012 - pubs.rsc.org
Small-angle scattering of X-rays (SAXS) is an established method to study the overall
structure and structural transitions of biological macromolecules in solution. For folded …
structure and structural transitions of biological macromolecules in solution. For folded …
Dynamic protein interaction networks and new structural paradigms in signaling
Understanding signaling and other complex biological processes requires elucidating the
critical roles of intrinsically disordered proteins (IDPs) and regions (IDRs), which represent∼ …
critical roles of intrinsically disordered proteins (IDPs) and regions (IDRs), which represent∼ …