[HTML][HTML] Antimicrobial resistance and its spread is a global threat

MM Aljeldah - Antibiotics, 2022‏ - mdpi.com
Antimicrobial resistance (AMR) is a challenge to human wellbeing the world over and is one
of the more serious public health concerns. AMR has the potential to emerge as a serious …

[HTML][HTML] Streptomyces: Still the Biggest Producer of New Natural Secondary Metabolites, a Current Perspective

L Donald, A Pipite, R Subramani, J Owen… - Microbiology …, 2022‏ - mdpi.com
There is a real consensus that new antibiotics are urgently needed and are the best chance
for combating antibiotic resistance. The phylum Actinobacteria is one of the main producers …

[HTML][HTML] Antibiotics: past, present and future

MI Hutchings, AW Truman, B Wilkinson - Current opinion in microbiology, 2019‏ - Elsevier
The first antibiotic, salvarsan, was deployed in 1910. In just over 100 years antibiotics have
drastically changed modern medicine and extended the average human lifespan by 23 …

antiSMASH 5.0: updates to the secondary metabolite genome mining pipeline

K Blin, S Shaw, K Steinke, R Villebro… - Nucleic acids …, 2019‏ - academic.oup.com
Secondary metabolites produced by bacteria and fungi are an important source of
antimicrobials and other bioactive compounds. In recent years, genome mining has seen …

Ecology and genomics of Actinobacteria: new concepts for natural product discovery

DA van Bergeijk, BR Terlouw, MH Medema… - Nature Reviews …, 2020‏ - nature.com
Actinobacteria constitute a highly diverse bacterial phylum with an unrivalled metabolic
versatility. They produce most of the clinically used antibiotics and a plethora of other natural …

Competition for iron drives phytopathogen control by natural rhizosphere microbiomes

S Gu, Z Wei, Z Shao, VP Friman, K Cao, T Yang… - Nature …, 2020‏ - nature.com
Plant pathogenic bacteria cause high crop and economic losses to human societies,–.
Infections by such pathogens are challenging to control as they often arise through complex …

[HTML][HTML] Antibiotics from rare actinomycetes, beyond the genus Streptomyces

J Parra, A Beaton, RF Seipke, B Wilkinson… - Current Opinion in …, 2023‏ - Elsevier
Throughout the golden age of antibiotic discovery, Streptomyces have been unsurpassed for
their ability to produce bioactive metabolites. Yet, this success has been hampered by …

[HTML][HTML] Multifunctional role of Actinobacteria in agricultural production sustainability: A review

K Boubekri, A Soumare, I Mardad, K Lyamlouli… - Microbiological …, 2022‏ - Elsevier
The growing interest in low-input agriculture in recent years has focused the use of microbial
biofertilizers to improve plant growth and yield through a better mobilization of indigenous …

Exploiting bacterial genera as biocontrol agents: Mechanisms, interactions and applications in sustainable agriculture

J Lee, S Kim, H Jung, BK Koo, JA Han, HS Lee - Journal of Plant Biology, 2023‏ - Springer
The rising demand for sustainable agriculture necessitates alternative methods to using
chemical pesticides for controlling plant pathogens. Biocontrol involves the use of natural …

[HTML][HTML] Actinobacteria in natural products research: Progress and prospects

PA Jose, A Maharshi, B Jha - Microbiological Research, 2021‏ - Elsevier
Actinobacteria are well-recognised biosynthetic factories that produce an extensive
spectrum of secondary metabolites. Recent genomic insights seem to impact the exploitation …