Mitochondrial DNA (mtDNA) is present in multiple copies within cells and is required for
mitochondrial ATP generation. Even within individual cells, mtDNA copies can differ in their …

Mutations in mitochondrial DNA (mtDNA) can manifest phenotypically as a wide range of
neuromuscular and neurodegenerative pathologies that are currently only managed …

DddA-derived cytosine base editors (DdCBEs) enable the targeted introduction of C• G-to-T•
A conversions in mitochondrial DNA (mtDNA). DdCBEs work in pairs, with each arm …

Mitochondrial dysfunction induced by mitochondrial DNA (mtDNA) mutations has been
implicated in various human diseases. A comprehensive analysis of mitochondrial genetic …

Abstract Background and Objective Mitochondria are crucial to the function of renal tubular
cells, and their dynamic perturbation in many aspects is an important mechanism of diabetic …

The factors determining levels of pathogenic mitochondrial DNA in cells and tissues are
critical to disease pathology but remain poorly understood and contentious. In Nature, Kotrys …

Difficulties in tracking the dynamics of heteroplasmy, a state when a single cell contains
distinct mtDNA genotypes, have left our understanding of factors influencing it incomplete …

Mitochondria contain their own small, circular genome that is present in high copy number.
The mitochondrial genome (mtDNA) encodes essential subunits of the electron transport …

Human stem cell-derived models have emerged as an important platform to study tissue
differentiation and disease mechanisms. Those models could capitalize on biochemical and …

The detection of mitochondrial DNA (mtDNA) mutations in single cells holds considerable
potential to define clonal relationships coupled with information on cell state in humans …